Cooperative Agreement U01CA292741

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $586K
Federal Grant Program
93.394
Assistance Type
Cooperative Agreement
Place of Performance
Houston, TX 77005, USA
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This Cooperative Agreement award from the National Cancer Institute (NCI), under the federal grant program "Cancer Detection and Diagnosis Research" (CFDA 93.394), aims to develop a point-of-care HPV DNA test for cervical cancer screening in Mozambique. The total award is $585,943, with a performance period from September 1, 2024 to August 31, 2029.

The key objectives are to: 1) Adapt existing extraction-free, multiplexed, isothermal nucleic acid amplification assays to detect 8 high-risk HPV types on a fully integrated nucleic acid amplification and lateral flow detection platform called NATFLOW; 2) Evaluate the clinical performance of the NATFLOW HPV test using 558 banked preserved samples and 1,890 prospective screening samples in Mozambique; and 3) Assess barriers and facilitators to cervical cancer screening using the NATFLOW HPV test. The project team includes researchers from the US, Mozambique, and Australia with expertise in developing, evaluating, and commercializing point-of-care technologies for low- and middle-income countries.

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