Project Grant R01CA279357

Award Date 7/3/24
Completion Date 6/30/29
Dollars Obligated $639K
Federal Grant Program
93.394
Assistance Type
Project Grant
Place of Performance
Hershey, PA 17033, USA
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This federal Project Grant award, valued at $201,172 and provided by the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), aims to support research on cell-free DNA methylation patterns as a biomarker for tumor biology and clinical outcomes in glioblastoma patients. The primary goal is to develop a non-invasive method for longitudinal molecular profiling of glioblastoma, a lethal brain tumor, to improve risk stratification, clinical trial design,...
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This $638,804 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports research by Pennsylvania State University to integrate cerebrospinal fluid (CSF)-based proteogenomic analysis to improve the diagnosis and management of diffuse gliomas, a type of brain tumor. The key objectives are to:

  1. Validate preliminary findings on the use of CSF proteomics to differentiate diffuse gliomas from other brain tumor types and identify novel diagnostic biomarker signatures.

  2. Establish the first CSF glycoproteome database for diffuse gliomas to support the development of new drug targets.

  3. Leverage CSF-based proteogenomic analysis to enhance preoperative diagnostic precision, enable early detection of true tumor recurrence, and reduce unnecessary surgery.

The 5-year project aims to have a significant impact on improving the clinical management of diffuse gliomas through more accurate diagnosis and treatment monitoring using a less invasive, CSF-based liquid biopsy approach.

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