Project Grant R01AT013753
- The National Institute of General Medical Sciences awarded the University of Chicago $451,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct systematic interrogation of diet as a mechanism to shape microbial community configuration and metabolism. The research examines how dietary macronutrients drive growth of specific microbial clades within a complex but defined human microbiome (HCOM2), utilizing in vitro analysis across a panel of...
- The National Institute of General Medical Sciences awarded The University of Chicago $149,650 on July 16, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop methods for predicting, designing, and controlling microbiome metabolism across human and environmental contexts. The research combines microbial physiology with quantitative statistical and modeling approaches to address gaps in understanding microbial traits—the metabolic capabilities and...
- The National Center for Complementary and Integrative Health awarded the University of California, San Diego $428,855 on April 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to develop computational and experimental approaches for identifying donor microbiota communities capable of stably engrafting in fecal microbiota transplantation (FMT) therapies. The research addresses a critical gap in predicting FMT outcomes by hypothesizing that...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded The Leland Stanford Junior University $787,346 on April 13, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to restore key functions to the industrialized gut microbiome. The project characterizes microbial strains capable of fermenting microbiota-accessible carbohydrates (MACs) into short-chain fatty acids (SCFAs)—acetate, propionate, and...
- This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 - Research and Training in Complementary and Integrative Health provides $451,000.00 in funding to The Trustees of Princeton University from September 2024 to August 2026. The objective is to characterize the secondary metabolomes of three Corynebacterial strains, including uncovering the small molecule products they use to compete with other microbes and interact with host cells....
- The National Center for Complementary and Integrative Health, a component of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $546,000 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R61AT013720. The award funds a two-phase investigation into precision probiotics engineered to support lactate metabolism and organ recovery in hospitalized...
- The National Institute of General Medical Sciences awarded the University of Illinois Chicago $440,908 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year investigation into the cellular and molecular mechanisms linking dysbiosis, organ injury, and systemic inflammation in multiple organ dysfunction syndrome during critical illness. The research validates dysbiosis as a critical risk factor exacerbating organ injury and systemic...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $128,695 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The project investigates how gut-derived microbial metabolites regulate host energy metabolism, with focus on the mechanistic basis for cross-kingdom metabolic interactions relevant to...
- The National Institute of General Medical Sciences, a component of the National Institutes of Health, awarded The University of Chicago $590,711 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports development of new synthetic methods to accelerate preparation of diverse analogues for medicinal chemistry studies. Over the five-year performance period ending June 30, 2031, the research addresses carbon-carbon...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded $439,500 to the University of California, San Diego on April 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds development of structural biology tools to enable high-resolution cryo-EM elucidation of type I polyketide synthases isolated directly from natural producer...
The National Institutes of Health National Center for Complementary and Integrative Health awarded The University of Chicago $1,206,896 on August 12, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R01AT013753. The award funds research investigating exclusive metabolic niches as a strategy for precision microbiome manipulation. The work encompasses three aims: investigating the ecological function of exclusive metabolic pathways and their potential for targeted prebiotic enhancement of beneficial bacteria; developing synthetic exclusive metabolic niches by engineering specialized metabolism into therapeutic bacterial strains and testing controlled engraftment across diverse microbial backgrounds; and discovering novel exclusive metabolic systems through computational analysis and experimental screening to expand the toolkit for precision microbiome engineering applications. The research will develop exclusive metabolic niches as tools for manipulating microbial community dynamics through controlled interspecies metabolic interactions. Performance occurs in Chicago, Illinois, with a period of performance from August 12, 2026, through May 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/31/26 | ||
| Not listed | $603.4k | 8/14/26 |