Project Grant R01AR086857
- Federal Project Grant Award Summary The University of Rochester received a $464,315 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective July 1, 2025, through June 30, 2030. This research initiative investigates the role of L-type calcium channel CAV1.2 in Achilles tendinopathy, a degenerative tendon condition associated with pain and...
- Federal Project Grant Award Summary The University of Rochester received a $1.68M project grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 1, 2025 through August 31, 2028. This award funds research into the pathophysiology of tubular aggregate myopathy (TAM), an inherited muscle disease characterized by progressive weakness, exercise...
- Federal Project Grant Award Summary The University of Rochester received a $600,000 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded on September 5, 2025, with a completion date of August 31, 2026. This award funds research on "Deciphering the Endotypes and Signature of Non-Response in a Humanized Murine Model of PSA (Psoriatic Arthritis)," which aims to develop a deeper understanding...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a $543,417 Project Grant effective June 1, 2026 through May 31, 2031, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research initiative focuses on promoting functional neuromuscular regeneration following chronic volumetric muscle loss (VML) in aged mice. The project will deliver three primary...
- Federal Grant Award Summary The University of Rochester received a $332,792 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded May 1, 2026, with completion targeted for April 30, 2031. This award supports research investigating the molecular drivers of repeat instability in myotonic dystrophy type 1 (DM1), a progressive neuromuscular disorder caused...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $372,171 Project Grant to The Research Foundation for the State University of New York (RF SUNY), effective June 1, 2026, through May 31, 2028, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research into the mechanistic investigation of galectin-3 (GAL3)-expressing macrophages in fracture callus fibrosis and...
- Federal Project Grant Award Summary This Project Grant, awarded July 15, 2025, by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $169,344 in federal funding to the University of California, Davis through June 30, 2030. The award supports mechanistic research investigating systemic and local immunomodulation of fracture healing in polytrauma patients, addressing a...
- Federal Project Grant Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $4.13 million Project Grant to Icahn School of Medicine at Mount Sinai effective September 1, 2025, through August 31, 2028, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project, titled "Uncovering Novel Microbial Factors That Enhance Wound Repair," delivers biomedical research services focused on identifying and...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded New Jersey Institute of Technology a $330,107 Project Grant effective September 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports fundamental research investigating the role of stress anisotropy—directional stress differences in extracellular matrices—in fibroblast activation and its...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $172,034 Project Grant to the University of Nebraska Medical Center on August 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This research initiative, with a completion date of June 30, 2030, focuses on identifying molecular and epidemiologic determinants of myocardial dysfunction and heart failure (HF) in patients with...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Rochester a $547,767 project grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) effective June 1, 2026, through May 31, 2031. This research initiative focuses on identifying host mechanisms governing Staphylococcus aureus persistence during implant-associated osteomyelitis, a significant clinical challenge in orthopedic surgery. The project leverages humanized mouse models and multi-omic investigation of human T cells to elucidate why certain patients resolve acute bone infections while others experience chronic persistence, reinfection, or severe complications including arthrodesis, amputation, or septic death. The primary deliverables include the development of functional clinical biomarkers to enable evidence-based diagnostic and treatment decision-making for implant-associated osteomyelitis. Research findings indicate that immune checkpoint proteins—specifically TIM-3, LAG3, and PD-1—are elevated in patients with S. aureus osteomyelitis and demonstrate predictive value for adverse clinical outcomes. By elucidating T cell functional impairment mechanisms in chronic osteomyelitis and validating a multiparametric prognostic nomogram, this project aims to advance clinical diagnostics and establish a scientific foundation to guide life-altering surgical decisions in orthopedic infection management.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $547.8k | 5/22/26 |