Project Grant R01AR086771
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $676,210 to The Washington University on August 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The recipient will conduct research into DNMT3A as an epigenetic transcriptional therapeutic target in femoroacetabular impingement (FAI) progression to osteoarthritis. FAI is a pre-arthritic hip condition affecting individuals aged 20 to 40; standard surgical treatment...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Syracuse University $467,076 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop multifunctional microcarriers for immune modulation in osteoarthritis treatment. The project addresses post-traumatic osteoarthritis (PTOA) by investigating site-specific delivery of a macrophage-targeting agent via calcium-zoledronate nanoparticle-loaded microparticles...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, awarded $675,318 to Duke University on August 20, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the relationship between obesity, cartilage mechanics, and osteoarthritis progression and the potential for weight loss and exercise interventions to reverse obesity-associated cartilage degeneration. The research...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $547,767 to the University of Rochester on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate host mechanisms governing Staphylococcus aureus persistence during implant-associated osteomyelitis. The research uses humanized mouse models and multi-omic analysis of human T cells to understand why some patients resolve acute bone infections while others...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Carnegie Mellon University $486,545 on July 3, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and validate in vivo cartilage mechanics as a sensitive biomarker for early knee osteoarthritis detection. The research establishes a novel metric based on cartilage deformation and composition changes in response to common physical...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $1.95 million Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 10, 2025, with an ultimate completion date of August 31, 2028. This research project investigates cellular stress mechanisms in osteoarthritis (OA) by examining the IRE1α-XBP1-NUPR1...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Oregon $343,491 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to engineer hemoglobin-based oxygen-carrying spheroids that enhance the viability and secretome activity of injectable mesenchymal stem cells in hypoxic osteoarthritis joint environments. The recipient will develop functional hemoglobin...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $412,610.00 to the Oklahoma Medical Research Foundation (OMRF) to investigate associations between the peripheral blood microbiome and knee osteoarthritis. The key objectives are to determine if baseline peripheral blood bacterial DNA patterns can predict future radiographic and...
- Federal Project Grant Award Summary Northeast Ohio Medical University (Neomed) received a $584,330 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 15, 2025, with a completion date of August 31, 2030. The award funds research investigating the role of mitochondrial DNA (mtDNA) leakage in promoting inflammation and intervertebral disc...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health under the Department of Health and Human Services, awarded $585,012 to Massachusetts General Hospital on June 2, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research investigating the role of the C10ORF10/DEPP1 protein in skeletal muscle atrophy. The recipient will conduct three specific aims: defining the...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Ohio University $665,615 on August 15, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the role of a novel SIRT5 allele in osteoarthritis development. The research examines how altered SIRT5 activity in chondrocytes disrupts cellular metabolism and joint inflammation to increase osteoarthritis susceptibility. The recipient will conduct studies on a rare coding mutation in SIRT5 (F101L substitution) identified in a family with early-onset osteoarthritis, using genome-edited mice carrying the human SIRT5 mutation to understand how decreased SIRT5 activity alters synovial joint homeostasis and promotes disease development. The work builds on prior findings demonstrating that SIRT5-dependent lysine demalonylation maintains chondrocyte metabolic balance and that SIRT5 expression declines with aging in both mice and humans. Performance takes place in Ohio. The period of performance extends through June 30, 2031. This is a Project Grant, a form of assistance funding supporting discrete research projects under NIAMS' mandate to support research into the causes, treatment, and prevention of arthritis and musculoskeletal diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $665.6k | 8/11/26 |