Project Grant R01AR086189
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $581,451 to Icahn School of Medicine at Mount Sinai on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate neuroimmune mechanisms underlying pruritus and microbiota-evoked sensory nerve hyperinnervation. The research examines how commensal microbiota-induced immune responses, particularly T cell immunity to Staphylococcus aureus and IL-17A cytokine...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University $148,062 on September 30, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funded research investigates the mechanism by which epithelial stem and progenitor cells encode inflammatory memory in psoriasis and other remitting-relapsing inflammatory disorders. The study tests whether homeostatic and inflammatory transcription factors dynamically...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Icahn School of Medicine at Mount Sinai $551,321 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the cellular and molecular mechanisms governing dermal condensate formation during embryonic hair follicle development. The research explores how axon guidance signaling regulates the migration and clustering of dermal papilla cell progenitors...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of California, San Diego $559,827 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the molecular mechanisms regulating inflammatory responses in epidermal keratinocytes. The research will characterize the role of the ZNF750 protein complex and its associated factors (KDM1A/LSD1, SETDB1, TRIM28/KAP1, and HNRNPU) in mediating...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, awarded The Rockefeller University $100,228 on November 27, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate whether embryonic exposure to hypoxia primes epidermal stem cells for inflammatory response in postnatal life. The research tests the hypothesis that developmental transcription factor activity, specifically...
- The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Icahn School of Medicine at Mount Sinai $100,228 on November 16, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate mechanosensation in fibro-adipogenic progenitors during skeletal muscle regeneration. The project will elucidate how muscle-resident mesenchymal stromal cells sense mechanical changes in their environment through...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas Health Science Center at Houston $623,286 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate hypoxia-driven NUDT21-mediated alternative polyadenylation in lung and skin fibrosis associated with systemic sclerosis. The project, designated R01AR087804, examines how tissue hypoxia—driven by Raynaud's phenomenon and...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas Southwestern Medical Center $578,211 on August 7, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to fund investigator-initiated research defining how epidermal NADPH depletion and redox imbalance disrupt skin barrier function and drive systemic metabolic effects. The project addresses the physiological roles of NAD kinase (NADK) and NADPH...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $442,595 to The Regents of the University of California, San Francisco on September 19, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846, Project Grant R01AR085315). The recipient will develop machine learning–based prognostic models to predict which children with early-onset atopic dermatitis are more likely to develop persistent disease and comorbid conditions including...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Icahn School of Medicine at Mount Sinai $544,559 on September 2, 2026, to investigate basophil-fibroblast interactions in atopic dermatitis under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project examines how basophil-derived cytokines and mediators activate fibroblasts and drive inflammatory immune cell recruitment in atopic dermatitis. Research employs genetic approaches to deplete basophils and disrupt basophil-derived interleukin-4, interleukin-13, and oncostatin M during acute inflammation in mouse models, paired with profiling of human atopic dermatitis tissue to assess basophil-fibroblast co-localization using immunofluorescence and spatial transcriptomic analysis. The work tests the hypothesis that disrupting the basophil-fibroblast axis reduces overall inflammation and prevents fibroblast activation of pro-inflammatory chemokines. Performance occurs in New York, New York from September 2, 2026 through August 31, 2031. The project is classified as a Project Grant (R01).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $544.6k | 9/2/26 |