Project Grant R01AR087994
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University $148,062 on September 30, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funded research investigates the mechanism by which epithelial stem and progenitor cells encode inflammatory memory in psoriasis and other remitting-relapsing inflammatory disorders. The study tests whether homeostatic and inflammatory transcription factors dynamically...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of California at Riverside $224,100 on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate epigenetic factors controlling epidermal stem cell longevity in adult skin. The research examines how epigenetic regulators, specifically polycomb repressive complexes, function in hair follicle stem cells and interfollicular...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of California, Los Angeles $493,148 on September 3, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize mechanisms of intra-epithelial migration in the developing epidermis. The project uses live imaging of developing zebrafish to investigate how specialized cell types arising from basal epidermal cells—specifically...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Leland Stanford Junior University $204,682 on September 10, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize the roles of RNA-binding protein assemblies in epidermal homeostasis. The recipient will develop and apply two new crosslinking immunoprecipitation-based methods—IRCLIP-RNP and RE-CLIP—to study how RNA-binding proteins organize and...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $581,451 to Icahn School of Medicine at Mount Sinai on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate neuroimmune mechanisms underlying pruritus and microbiota-evoked sensory nerve hyperinnervation. The research examines how commensal microbiota-induced immune responses, particularly T cell immunity to Staphylococcus aureus and IL-17A cytokine...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Washington University $916,572 on July 6, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate immune mechanisms driving psoriasis and related inflammatory skin conditions. The research focuses on CD5+ dendritic cells, a subset that accumulates in psoriatic lesions and drives autoimmune T cell activation, disrupting skin immune tolerance. The project will define...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Pennsylvania $2,063,666 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate protein translation efficiency in T cell adaptation to human skin. The research addresses tissue-resident memory T cells (TRM) that persist in skin despite current immunosuppressive treatments and drive chronic inflammatory and autoimmune skin disease. The...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (part of the National Institutes of Health) awarded the University of California, Los Angeles $150,152 on March 27, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize migratory cell differentiation in developing zebrafish skin. The research will use live imaging, antibody staining, single-cell RNA sequencing, and pseudotime analysis to characterize the development of...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Northwestern University $524,335 on June 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the molecular mechanisms governing how the PBAF chromatin remodeling complex switches between repressing and activating epidermal differentiation genes. The project, titled "Dynamic Regulation of Epidermal Differentiation Genes by Cell-State-Specific PBAF...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Washington University $258,070 on September 26, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to fund a five-year physician-scientist training and mentored research program examining the role of centrosomal protein CEP43 in epidermal homeostasis and cutaneous inflammatory diseases. The research project investigates mechanisms by which loss of CEP43 leads...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of California, San Diego $559,827 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the molecular mechanisms regulating inflammatory responses in epidermal keratinocytes. The research will characterize the role of the ZNF750 protein complex and its associated factors (KDM1A/LSD1, SETDB1, TRIM28/KAP1, and HNRNPU) in mediating skin inflammatory responses and determine which genes the ZNF750 complex directly binds and silences to regulate cutaneous inflammation. The work addresses the biological basis for how excessive or prolonged inflammatory responses in keratinocytes contribute to skin diseases such as psoriasis. Research activities will examine how ZNF750 and its associated proteins form a silencing complex that dampens innate immune gene expression in differentiated keratinocytes in response to various inflammatory stimuli. Performance will occur at UC San Diego's La Jolla, California campus. The award period extends from September 1, 2026, through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $559.8k | 9/2/26 |