Project Grant R01AR085598
Award Date
5/15/25
Completion Date
4/30/30
Dollars Obligated
$641K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Salt Lake City, UT 84112, USA
Similar Awards
This $782,871 federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate mechanisms by which arthritogenic alphaviruses, such as chikungunya and Ross River viruses, evade CD8+ T cell-mediated immunity. The primary goals are to: 1) determine how type I interferon restricts alphavirus infection of antigen-presenting cells, impairing the...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $531,109 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Florida to develop technologies that enable safe and effective gene editing in skeletal muscle. The project aims to address four key challenges with using adeno-associated virus (AAV) for delivering gene editing machinery to skeletal muscle: maximizing delivery and spread of editing enzymes,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $147,656 to the University of Colorado-Denver to elucidate the mechanisms driving the development of chronic Chikungunya virus (CHIKV) arthritis. The key objectives are to: (I) define a viral reservoir in macrophages in joint-associated tissue, (II) assess mechanisms driving pro-inflammatory programming in macrophages,...
This $820,142 federal Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" will fund research to investigate the impact of early-life physical inactivity on adult muscle quality, function, and frailty development in mice. The primary objectives are to: 1) examine the effect of varying levels of early-life physical inactivity on muscle quality and function in...
This $488,575 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to understand how myosin binding protein-C (MYBP-C) regulates skeletal muscle contraction and how genetic mutations in MYBP-C lead to skeletal muscle diseases. The University of Arizona will use a novel "cut and paste" technique to selectively modify slow and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is funding research to explore the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction and inflammation in sepsis. The $193,188 award, which runs from Sep 1, 2024 to Aug 31, 2026, will support experiments testing the hypothesis that skeletal muscle-specific knockout of...
This $299,969 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to evaluate a mosquito salivary protein, AGBR1, as a vaccine candidate against Chikungunya virus. The goal is to confirm that vaccination with AGBR1 can protect against Chikungunya infection in mouse models, including both acute lethal infection and chronic disease manifestations like joint pain and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the use of collagenase to target collagen architecture in fibrotic skeletal muscle. The $151,471 award, granted on September 26, 2024, with a completion date of April 30, 2026, will support research to elucidate the mechanisms by which fibrotic collagen architecture drives muscle...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $201,960 to the University of Vermont & State Agricultural College to develop a novel "designer myosin-binding protein C (MyBP-C)" zebrafish model system. The research aims to precisely control the expression of specific MyBP-C isoforms in zebrafish skeletal muscle,...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $522,714 Project Grant (R01AR083916) to Rensselaer Polytechnic Institute (RPI) to investigate the role of stretch activation in maintaining skeletal muscle endurance. The research, conducted under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to determine the kinetic and structural mechanisms that differentiate stretch activation characteristics in different...