Project Grant R01AR085352
Award Date
1/1/25
Completion Date
3/31/29
Dollars Obligated
$666K
Similar Awards
This federal Project Grant award of $456,808.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of advanced mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...
This $483,070 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" supports research into the dynamics of bone extracellular matrix (ECM) assembly and resorption. The study aims to investigate how osteogenic cellular dynamics, differentiation, and cell fate are integrated with collagen assembly and mineralization, as well as how osteoclast bone resorption...
This Project Grant award, ID R21AR084126, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $783,176 award supports research to develop and validate a quantitative spine imaging methodology using photon-counting detector CT (PCD-CT) technology to comprehensively characterize bone quality, including cortical and trabecular microstructures, in patients with...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to investigate the mechanisms by which mechanical and hormonal signals are integrated within bone cells to stimulate bone formation. The total award amount is $175,948 and will be performed over 5 years from June 1, 2025 to May 31, 2030. The research aims to identify how the focal...
This $358,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research at Brigham & Women's Hospital to elucidate social determinants of health and mental health needs in order to achieve equity in rheumatic disease care. The award will fund a 2-year study that leverages data from the All of Us research program to: Assess the effects of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846) will provide $1,469,862.00 to The Regents of the University of California, San Francisco over 5 years starting on Sep 5, 2024. The project aims to elucidate the biological and material mechanisms by which exercise controls bone quality, focusing on the role of osteocytes and their mitochondrial function. The research will leverage established mouse models to investigate how...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to identify myeloid progenitors that maintain cortical bone mass with age and characterize factors that promote coupling within cortical bone. The $375,100 award, active from Sep 20, 2024 to Aug 31, 2026, supports research at the University of Minnesota to address the significant impact of...
This federal Project Grant award, valued at $1,938,605.00 and awarded on August 19, 2024 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), aims to define the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates bone mass in females. The primary objectives are to investigate how the loss of KDM5C affects osteoclast function, osteoclast-osteoblast communication, and osteoclast energy metabolism. The research team will also examine the...
This federal Project Grant award of $765,546, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to develop a novel non-invasive method for assessing bone turnover in patients with chronic kidney disease (CKD). The project aims to evaluate a "virtual bone biopsy" approach using time-lapse high-resolution peripheral quantitative computed...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $522,334 to develop a computational data repository called BoneBase that will collect and share bone phenotyping data from rodent animal models. The project aims to build a sustainable, cloud-based platform to ingest, curate, and publicly share quantitative skeletal data generated...