The University of California, Davis (UC Davis) was awarded a $123,424 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to elucidate the mechanisms by which fibrotic collagen architecture in skeletal muscle contributes to muscle stiffness and impairs muscle stem cell regenerative capacity. The project aims to assess the ability...
The University of California, Irvine received a $473,377 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award, with a performance period from August 16, 2024 to July 31, 2029, will fund research to investigate methods for improving skeletal muscle regeneration using human pluripotent stem cell (hPSC) transplantation therapies. Key objectives...
The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $752,620 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Washington University. The grant, awarded on September 20, 2024, with a completion date of August 31, 2026, will support the development of alginate hydrogels with tethered insulin-like growth factor 1 (IGF-1) mimetic peptides. These engineered hydrogels are designed to enhance the...
This Project Grant award of $605,253 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award will support research to investigate the mechanical crosstalk between the intervertebral disc and adjacent facet joints during spinal degeneration and potential mitigation through disc repair. The study will utilize large animal models and human cadaveric tissues...
This $526,174 Project Grant was awarded on June 1, 2024 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funding will support Duke University's efforts to engineer and study heterocellular human skeletal muscle tissue models that incorporate key cellular components, such as capillary networks and functional motor neurons, to better recreate and investigate the native...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant with an effective date of Jul 4, 2024 and ultimate completion date of Aug 31, 2027. The grant, titled "GRANULAR HYDROGELS FOR THE CONTROLLED DELIVERY OF IMMUNOMODULATORY AND ANGIOGENIC EXTRACELLULAR VESICLES TO ENHANCE BONE TISSUE REGENERATION", will support research conducted by the University of Colorado to develop granular hydrogel-based therapies for controlled...
This $547,424 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to identify and characterize a unique skeletal stem cell type specific to vertebrae. The awardee, Weill Medical College of Cornell University, aims to:
Determine the unique cellular features and functions of this vertebral skeletal stem cell (VSSC) compared to stem...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $172,700 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of California, Irvine (UCI) to develop a novel therapeutic approach for improving angiogenesis (blood vessel growth) during wound healing. The project aims to deliver apoptotic (dying) neutrophils within a degradable hydrogel scaffold, which will stimulate macrophages to secrete angiogenic...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Oregon a $360,580 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project aims to develop a novel anisotropic, degradable poly(ethylene glycol) hydrogel-based engineered extracellular matrix (EECM) that can promote the alignment and regenerative characteristics of human tenocytes. Key activities include characterizing the material...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $501,450 to The Washington University to conduct research on regulating tendon repair using stem cell-derived extracellular vesicles. The study aims to identify the specific subpopulation and active cargo molecules of extracellular vesicles that can enhance tendon healing and avoid...