Project Grant R01AR085120
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $352,777 to support research into the regulation of sarcomere growth in skeletal muscle. The research aims to: 1) Identify molecular targets that impact sarcomere addition during muscle growth, and 2) Use in vivo protein tagging methods to study the dynamics of newly synthesized sarcomere...
- This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
- This $488,575 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to understand how myosin binding protein-C (MYBP-C) regulates skeletal muscle contraction and how mutations in the genes encoding slow and fast MYBP-C (MYBPC1 and MYBPC2) cause congenital skeletal muscle diseases. The research team at the University of Arizona will use...
- This federal Project Grant award of $175,500 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of alternative splicing in Facioscapulohumeral Muscular Dystrophy (FSHD). The research project, performed by The Washington University, has three key objectives: 1) Characterize the interactions between the transcription factor DUX4 and RNA in...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is funding research on the role of HOX-expressing interstitial cells in muscle growth, homeostasis, and regeneration. The $557,357 award, effective from March 14, 2025 through February 28, 2030, will support a University of Wisconsin-Madison research project investigating the ability of a...
- This federal Project Grant award of $671,240 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to develop enhanced dystrophin gene therapies for Duchenne muscular dystrophy (DMD). The University of Washington will conduct this research from January 2025 through December 2029. The project aims to design and test micro-, mini-, and full-length dystrophin gene...
- This federal Project Grant award of $471,513 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to investigate the mechanisms underlying neuromuscular diseases where glycosylation is disrupted. The University of Maine System, through its Research & Sponsored Program division, will use a zebrafish model to study how loss of the dolichylphosphate mannose...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $439,791 Project Grant to The University of Texas Southwestern Medical Center on March 1, 2025 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant supports research to investigate the molecular mechanisms of myoblast fusion, which is essential for skeletal muscle development and regeneration. The research aims to understand the cellular and...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $183,125 Project Grant to the San Jose State University Research Foundation. The grant, with a performance period from August 1, 2025 to July 31, 2029, will support a research project titled "Diet Promotes Muscle Stem Cell Activation and Proliferation in Drosophila." The project aims to decipher the mechanism by which diet and...
- This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to elucidate the role of lysine acetylation in regulating skeletal muscle contractile function. The $1,853,872.00 award, spanning from September 15, 2025 to August 31, 2028, will be provided to the University of California, San Diego (UCSD) to investigate how the...
This Project Grant award of $323,918 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to elucidate the isoform-specific functions of the RNA-binding protein Bruno1 (Bru1) in Drosophila muscle development. The research aims to expand understanding of how Bru1 isoforms regulate fiber-type specific splicing events critical for proper sarcomere formation and function in insect flight muscles. This work leverages Drosophila as a tractable genetic model system to investigate conserved mechanisms of RNA-binding protein regulation during myogenesis, which can provide insights into disrupted RNA regulation observed in muscle diseases like myotonic dystrophy. The awarded project period runs from September 2025 through July 2030 and is being conducted by the University of Missouri at Kansas City.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $323.9k | 9/5/25 |