Project Grant R01AR085115
- This Project Grant award of $434,682 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of the award is to precisely define the proteolytic events and mechanisms along the timeline of post-traumatic osteoarthritis (PTOA), leveraging a specialized proteomics approach called "degradomics." The award recipient, the Cleveland Clinic...
- This Project Grant award, valued at $196,460.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The purpose of the award is to test a miniature knee joint system as a new tool to study the role of neuro-immune interactions in osteoarthritis pain. The University of Pittsburgh, the awardee, will use this novel microphysiological system with cartilage,...
- This federal Project Grant award of $1,950,412.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), to Wake Forest University Health Sciences. The funding supports research to define how the IRE1A-XBP1-NUPR1 signaling axis in immune cells and chondrocytes contributes to synovial inflammation, cartilage damage, and osteoarthritis pain. The...
- The federal Project Grant award of $426,889.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the molecular regulatory mechanisms of a cartilage-enriched G-protein coupled receptor (GPCR) named ADGRG6 and its role in maintaining joint and cartilage homeostasis. The project, awarded to the University of Southern California, aims to investigate the...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), is intended to elucidate the effects of blood and blood-derived components on meniscus tissue homeostasis, repair, and post-traumatic osteoarthritis development. The $487,652 award to Duke University will fund research to investigate the mechanisms by which blood-derived immune...
- This $361,300 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) will support research to identify new cell signaling pathways and therapeutic targets for disease modification in osteoarthritis (OA). The University of North Carolina at Chapel Hill will conduct high-throughput screening of small molecules to discover signaling pathways...
- This federal Project Grant award of $646,506 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of dual-action nanoparticle-loaded microparticles for the treatment of osteoarthritis (OA). The research aims to create innovative nanoparticle-based therapeutics that can stimulate the anabolic activity of chondroprogenitors to enhance cartilage...
- This Project Grant award of $691,089.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supports research to investigate the role of mechanosensing and mechanotransduction in joint homeostasis and osteoarthritis (OA) susceptibility. The research aims to determine how mutations in the PIEZO1 mechanosensitive cation channel affect PIEZO1 activity and influence OA development. The project will use biophysical analyses, cellular/molecular studies, and mouse...
- The Project Grant award titled "The Impact of TLR Signaling on Osteoclast-Mediated Bone Remodeling and Inflammation in Osteoarthritis" is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The $147,486 award will support research at the University of Pennsylvania focused on understanding how Toll-like receptor (TLR) signaling in osteoclasts...
- This federal Project Grant award of $1,617,503 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is supporting research to improve understanding and treatment of pain associated with psoriatic arthritis. The key products or services to be delivered through this award include: Improving and validating a mouse model for studying pain mechanisms in psoriatic arthritis....
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $540,974 to Duke University to conduct research on Janus kinase (JAK) signaling in post-traumatic osteoarthritis (PTOA). The research aims to identify the specific JAK molecules that mediate the cartilage degradation and pain associated with PTOA, and to test selective JAK inhibitors as potential disease-modifying osteoarthritis drugs (DMOADs). The project will utilize genetic approaches and in vivo/ex vivo models to understand the downstream mechanisms of JAK signaling in PTOA and evaluate JAK-targeted pharmacological interventions. The award has a performance period from September 2025 to August 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $541.0k | 9/17/25 |