Project Grant R01AR085095
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $439,791 Project Grant to The University of Texas Southwestern Medical Center on March 1, 2025 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant supports research to investigate the molecular mechanisms of myoblast fusion, which is essential for skeletal muscle development and regeneration. The research aims to understand the cellular and...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is funding research on the role of HOX-expressing interstitial cells in muscle growth, homeostasis, and regeneration. The $557,357 award, effective from March 14, 2025 through February 28, 2030, will support a University of Wisconsin-Madison research project investigating the ability of a...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $198,263 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Board of Regents of the University of Nebraska. The research project aims to investigate the role of the protein Mitsugumin 53 (MG53) in preventing muscle atrophy during periods of disuse, which can contribute to age-related sarcopenia and frailty. The research will explore how...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $352,777 to support research into the regulation of sarcomere growth in skeletal muscle. The research aims to: 1) Identify molecular targets that impact sarcomere addition during muscle growth, and 2) Use in vivo protein tagging methods to study the dynamics of newly synthesized sarcomere...
- This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $554,797 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The University of Kentucky Research Foundation. This 5-year grant, awarded on September 1, 2025, will support research to define the rate of myonuclear turnover in adult skeletal muscles, identify the mechanisms by which myonuclei are degraded, and unravel the targeting complexes and cellular...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $216,113 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Weill Medical College of Cornell University. The grant funding will support research to target the GDF15-GFRAL signaling pathway to prevent and treat cachexia (muscle wasting) in a mouse model of mitochondrial myopathy. Specifically, the research aims to determine if inhibiting the GDF15-GFRAL...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $671,437 to Virginia Polytechnic Institute & State University (Virginia Tech) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant supports research to investigate the role of endothelial cell-derived reactive oxygen species (ROS) in regulating skeletal muscle metabolism in response to exercise. Specifically, the research...
- This $820,142 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program. The grant aims to investigate the effects of early-life physical inactivity in mice on muscle quality, function, and frailty development in adulthood. Specifically, the research will examine the regulatory aspects of the extracellular matrix, muscle macrophages, and physical...
- This federal Project Grant award of $237,874 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the upstream regulation of mitochondrial bioenergetics by the mitochondrial acyl carrier protein (MTACP). The research aims to uncover how MTACP, which sits at the intersection of nutrient inputs and energy expenditure in mitochondria, is regulated through the 4'-phosphopantetheine...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), provides $1,622,775.00 to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan to study the critical role of mitochondrial oxidative metabolism in regulating muscle satellite cell fate and function. The research aims to definitively determine the metabolic requirements for myogenic differentiation, specifically investigating how errors in the mitochondrial fatty acid synthesis (MTFAS) pathway can block myoblast differentiation and impede muscle regeneration following injury. The project will run from September 1, 2025 through August 31, 2028, advancing scientific understanding of the metabolic regulation of muscle stem cell biology, which has implications for addressing age-related muscle wasting and muscular dystrophy.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 8/12/25 |