Project Grant R01AR084525
- This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $300,000.00 to the Regents of the University of Minnesota to investigate the roles of the Lyn kinase isoforms A and B in regulating immune cell signaling and their impact on the development of systemic lupus erythematosus (SLE). The research aims to 1) define the distinct functions of the Lyn isoforms in activating immune receptors and...
- This federal Project Grant award, valued at $127,273.00 and awarded on September 5, 2025, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to study the role of the TFEB transcription factor in regulating the metabolic fitness and function of age-associated B cells (ABCs), a recently described B cell subset that accumulates during...
- This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
- This federal Project Grant award for $3,364,935.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) through the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to functionally and mechanistically characterize genetic factors that contribute to the development of systemic lupus erythematosus (SLE). The research aims to elucidate the role of autophagy, a cellular process, in the pathogenesis of SLE, particularly in immune cells and...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $715,957.00 to Northwestern University to conduct research on the mechanisms by which type I interferon cytokines support the production and expansion of T peripheral helper (Tph) cells in systemic lupus erythematosus (SLE) patients. The research aims to elucidate the molecular pathways...
- The federal Project Grant award of $300,000 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to Temple University in Philadelphia, PA. The funding supports research focused on understanding the role of the kallikrein-kinin system and its ability to suppress the type I interferon response, which is a hallmark of systemic lupus erythematosus (SLE). The research aims to explore new pathways for interferon suppression and their...
- This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...
- This federal Project Grant award of $2,989,958 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Thomas Jefferson University's Sidney Kimmel Medical College. The grant supports research to delineate the mechanisms by which pyrimidine synthesis promotes systemic autoimmunity in systemic lupus erythematosus (SLE). The research aims to improve understanding of the role of pyrimidine...
- This federal Project Grant award in the amount of $700,000.00, provided by the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training program), supports research to investigate the role of the ARID3A protein in systemic lupus erythematosus (SLE) and other autoimmune diseases. The award will fund a research project at the University of Oklahoma Health Sciences Center to: 1) define genes and epigenetic regions directly regulated by ARID3A expression...
- This $256,808 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to better define the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The University of Washington is conducting this research, which focuses on analyzing altered mRNA splicing in SLE neutrophils and exploring the consequences of these splicing changes, including...
This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the functions of the LYNA and LYNB kinases in myeloid-cell pro-inflammatory signaling and their relationship to systemic lupus erythematosus (SLE). The $668,135 award, effective from Sep 1, 2025 to Aug 31, 2030, aims to assess the roles of these kinase isoforms in ITAM, TLR, and ER signaling pathways within myeloid cells, which are key drivers of autoimmunity. The research will utilize candidate and unbiased kinase-substrate mapping and interactomic approaches in macrophages and dendritic cells to comprehensively profile the substrates and functions of LYNA and LYNB in receptor activation. This work seeks to explain the paradoxical positive and negative inflammatory effects observed with these kinases and suggest potential therapeutic approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $668.1k | 7/25/25 |