The Regents of the University of California, San Francisco (UCSF) has been awarded a Project Grant of $463,274 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a division of the U.S. Department of Health and Human Services National Institutes of Health. The funding will support UCSF's research project titled "Exploring Modulation of Lamin A/C Protein Lifetime as a Novel Axis of Regulation in Health and Disease" under the NIAMS Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The key products and services to be delivered include investigating how mutations in the LMNA gene affect the stability and folded state of lamin A/C proteins, and how these changes impact the proteins' role in scaffolding chromatin within the cell nucleus. This research aims to enhance the understanding of the molecular mechanisms underlying laminopathy diseases that primarily affect the cardiovascular system, muscle, skin, and other tissues.
Generated 3/4/25, 4:21 AM