Project Grant R01AR084097
- The National Institute of General Medical Sciences (NIGMS) awarded a $557,900 Project Grant to the Massachusetts Institute of Technology (MIT) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds a long-term research strategy to study ongoing adaptation and selective forces within human microbiomes. Using a culture-dependent genomic approach, the project aims to characterize within-person evolution over a dozen microbial species found in the skin, vagina,...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $2,070,827 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Icahn School of Medicine at Mount Sinai. This grant aims to identify novel microbial factors that can enhance wound repair, a significant public health issue with over 100 million new acute skin wounds annually and substantial treatment costs exceeding $25 billion. The...
- This federal Project Grant award of $107,862, provided by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), aims to advance the understanding of the human skin microbiome and its interactions with commensal bacteria. The key goals are to elucidate the structure and biosynthetic mechanisms of a bacteriocin produced by the common skin commensal Staphylococcus hominis, and to...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) provides $198,782 to Duke University to develop a platform that leverages 3D human reconstructed epidermis (RHE) cultures to investigate interactions between the skin microbiome and skin cell populations. The goal is to enable the investigation of host-microbe interactions at a large scale by knocking out human genes...
- The Massachusetts Institute of Technology (MIT) was awarded a $800,000 Project Grant from the National Science Foundation (NSF) to conduct collaborative research titled "Learning How Mucus Shapes and Maintains Microbiomes" from September 1, 2021 through August 31, 2026. Under the award, MIT researchers will work to advance understanding of the role that mucus plays in shaping and maintaining microbiomes. The research is funded through the NSF's Biological Sciences program (CFDA...
- This Project Grant award, titled "Skin Microbes and Development of Allergic Disease," is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $5,176,858 award will support research at the University of California, San Diego (UCSD) to investigate how colonization by specific strains of Streptococcus bacteria that can damage the skin barrier may increase the risk of developing allergic...
- This $250,396 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify differences in DNA regulatory elements that control gene expression in skin cells from individuals of different ancestral backgrounds. The research team at the Icahn School of Medicine at Mount Sinai will utilize advanced genomic techniques, including...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $393,718.00 to the Massachusetts Institute of Technology (MIT) to conduct research on the biogeography of microbial and plant-derived redox-active small molecules and their combinatorial effects on microbial growth. The project aims to determine the combinations of plant and microbial small molecules that microbial...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,431,000 Project Grant to the Massachusetts Institute of Technology (MIT) to develop self-assembling nanomaterials that can protect microbes from processing, transportation, and storage stresses. The goal is to enable the production of important but challenging microbial therapeutics that are difficult to manufacture. The 3-year project, with an award date of September 18, 2023, aims to elucidate the mechanism by which...
- This federal Project Grant award of $914,479 from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund a research project led by The Trustees of Columbia University in the City of New York to study the spatial organization and stability of synthetic gut microbiome communities in gnotobiotic mice. The research aims to elucidate the principles governing the assembly and persistence of microbial communities in the human digestive tract, which are essential for human...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $465,291 to the Massachusetts Institute of Technology (MIT) to conduct research on the determinants of colonization for commensal skin bacteria. The research aims to define the rules governing on-person bacterial evolution, ecology, and colonization, with the long-term goal of informing the development of effective microbiome-based therapies. The 5-year project period runs from August 1, 2025 to May 31, 2030 and will leverage MIT's expertise in genomics, microbiology, and computational biology to gain a high-resolution understanding of how abundant skin bacteria species establish and maintain colonization on the human body. The findings are expected to provide critical insights for advancing microbiome-based approaches to prevent infection, treat inflammation, and deliver therapeutic metabolites.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $465.3k | 7/31/25 |