This Project Grant award of $473,377 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to modulate the stem cell niche and improve skeletal muscle regeneration. The key objectives are to: Interrogate how muscle cells arise and develop functional characteristics from human pluripotent stem cells (hPSCs) through analysis of myogenic commitment factors and inhibition of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $626,483 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the Icahn School of Medicine at Mount Sinai to study the role of netrin signaling in regulating muscle stem cell quiescence and activation. The research aims to provide evidence that regulation of muscle stem cell projection dynamics is key to maintaining quiescence, and that netrin-1 is a novel regulator of...
This federal Project Grant award, valued at $230,212 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The goal of the research is to investigate how the immune system, specifically dendritic epidermal T cells (DETCs), drives functional heterogeneity in skin epithelial stem cells within and across different niches. The research will shed...
This federal Project Grant award, valued at $626,879.00, was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to explore a novel mouse model of large-scale bone regeneration to unravel the cellular and molecular mechanisms governing the initiation and coordination of bone repair following extensive injuries. Specifically, the research will...
This Project Grant award of $649,391, awarded on May 12, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research to enhance healing after injury. The research, conducted by The Johns Hopkins University, aims to define the mechanisms that restrain healing in epithelial tissues like skin and gut, with the goal of developing new therapies to improve regeneration following diverse injuries or infections. The work is funded through the NIAMS...
This federal Project Grant award of $242,310 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to uncover how allergic "type 2" skin inflammation impacts the long-term functional responsiveness and epigenetic state of epithelial stem cells. The award recipient, Rockefeller University, will use thymic stromal lymphopoietin (TSLP) as a driver to...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $177,872 to the University of Houston System to study the interaction between human induced pluripotent stem cell (hiPSC)-derived endothelial cells and skeletal muscle progenitor cells, both in vitro and in vivo. The research aims to elucidate the underlying mechanisms governing the...
This Project Grant award, valued at $306,324.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project aims to decipher the myofibroblast life cycle in skin wound healing. Key objectives include creating a molecular map of the myofibroblast life cycle and investigating the role of Hippo-YAP/TAZ signaling in myofibroblast deactivation and survival. The...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $647,460 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Cornell University to support research on the mechanisms of mechanically-induced gene expression in skeletal muscle cells. The five-year project, running from September 1, 2024 to August 31, 2029, aims to define the nuclear mechanisms responsible for the ultra-rapid activation of mechanoresponsive genes in...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $206,023 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Cornell University to investigate mechanotransduction pathways in injured cartilage. The project aims to determine how local peak strain magnitude and manipulation of calcium-dependent signaling or mitochondrial bioenergetics affect the distribution of chondrocyte phenotypes after impact injury, using a novel...