Project Grant R01AR083900

Award Date 6/12/24
Completion Date 5/31/29
Dollars Obligated $652K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
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This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,476,001.00 to The Regents of the University of California, San Francisco to conduct research on the systemic origins of osteoarthritis (OA). The research aims to define how adipose (fat) tissue communicates with joint tissues to drive OA pathology, exploring three potential mechanisms: signaling through secreted factors, cell...
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This Project Grant award, valued at $651,662.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award aims to investigate the role of lipid metabolism in articular cartilage homeostasis and osteoarthritis pathogenesis.

The key research objectives are to: 1) Establish the transcription factor NFIA as a downstream mediator of the TGF-β pathway in regulating articular chondrocyte lipid metabolism and homeostasis in mice, and 2) Define NFIA-mediated lipid metabolism as a potential therapeutic target for osteoarthritis treatment. The research will employ in vitro and in vivo genetic approaches, metabolomics analyses, and single-cell RNA sequencing to advance the understanding of osteoarthritis disease mechanisms and identify novel therapeutic targets related to lipid metabolism. The award was granted to The Washington University located in St. Louis, Missouri, with a performance period from June 2024 to May 2029.

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