Project Grant R01AR083438
Award Date
7/18/24
Completion Date
6/30/29
Dollars Obligated
$483K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Kansas City, MO 64108, USA
Similar Awards
This federal Project Grant award of $456,808 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskelastic and Skin Diseases Research program (CFDA 93.846), will fund the development of innovative mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in bone and cartilage tissue samples. The project aims to advance understanding of disease progression in osteoarthritis and meniscal injury by...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant with an effective date of Jul 4, 2024 and ultimate completion date of Aug 31, 2027. The grant, titled "GRANULAR HYDROGELS FOR THE CONTROLLED DELIVERY OF IMMUNOMODULATORY AND ANGIOGENIC EXTRACELLULAR VESICLES TO ENHANCE BONE TISSUE REGENERATION", will support research conducted by the University of Colorado to develop granular hydrogel-based therapies for controlled...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $322,408 to Syracuse University to research the role of calcium signaling by 3D osteocyte networks in the mechanoadaptive response of the bone multicellular unit. The project aims to define how fluid flow stimuli modulate calcium signaling across 3D osteocyte networks, determine...
This $599,693 five-year Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to elucidate molecular pathways and mechanisms regulating myeloid cell function and osteoclastogenesis under pathological inflammatory conditions. The overarching goal is to use this knowledge to develop new therapeutic approaches to suppress pathological bone resorption,...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,804,329 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the Regents of the University of Michigan to conduct research on identifying skeletal trait patterns that predict fracture risk in older men and women, independent of bone mineral density. The project aims to leverage high-resolution imaging, mechanical testing, and statistical modeling to understand how...
This federal Project Grant award, valued at $2,196,822 and made by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports a large-scale genetic analysis of bone strength in diversity outbred mice. The primary objectives are to: 1) Identify novel genes influencing bone strength and related traits through genome-wide association studies (GWAS) in a cohort of ~5,792 mice; 2)...
This federal Project Grant award R01AR084693 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $652,729 grant awarded to the Van Andel Research Institute (VAI) aims to determine the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates female bone mass. The research will investigate how loss of KDM5C affects osteoclast function and...
This $526,174 Project Grant was awarded on June 1, 2024 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funding will support Duke University's efforts to engineer and study heterocellular human skeletal muscle tissue models that incorporate key cellular components, such as capillary networks and functional motor neurons, to better recreate and investigate the native...
This $375,100 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to identify myeloid progenitors that maintain cortical bone with age and characterize cells/molecules that promote bone remodeling within the cortical bone compartment. The two-year study, conducted by the Regents of the University of Minnesota, aims to improve...
This $313,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund research by Emory University to establish phosphorylated WNT5A produced by osteoclasts as a potential anabolic bone drug. The research aims to determine how osteoclast-derived phospho-WNT5A can enhance bone formation in vivo and elucidate the cellular and molecular mechanisms by...