This $393,412 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), to Vanderbilt University on September 17, 2024. The goal of the project is to establish engineered, joint-resident cells as therapeutic agents to promote cartilage repair and mitigate inflammation in osteoarthritis. Key products and services to be delivered...
This federal Project Grant award of $456,808 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskelastic and Skin Diseases Research program (CFDA 93.846), will fund the development of innovative mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in bone and cartilage tissue samples. The project aims to advance understanding of disease progression in osteoarthritis and meniscal injury by...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $571,650 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Pittsburgh to repurpose FDA-approved drugs for the treatment of osteoarthritis (OA). The goal is to use high-throughput screening in human cell-derived microphysiological models to identify FDA-approved drugs that can reverse cartilage and/or inflammation-driven OA endotypes. The project...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $618,629 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado, to be completed by July 31, 2029. The objective is to establish a new 'joint-on-chip' microphysiological system that can support mechanistic study of arthritic diseases and rapidly test candidate treatments. Key goals include optimizing human-derived biomaterial...
This Project Grant award, with a total funding amount of $412,610.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The objective of the research is to better understand how peripheral blood microbiome patterns are associated with knee osteoarthritis (OA). The work aims to determine whether differences in baseline peripheral blood bacterial DNA patterns...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $212,507 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Mayo Clinic in Rochester, MN to develop and validate a new 6D Computed Tomography (6DCT) diagnostic imaging technique. The goal is to create an accurate, non-invasive tool to assess early dynamic joint pathologies before the onset of arthritis, which can enable earlier interventions and improve patient...
This $398,415 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund the development and manufacturing of RGNA09M, a liposomal adenosine formulation designed to regenerate cartilage and treat osteoarthritis.
Specifically, the grant will support the validation of analytical methods and cGMP manufacturing processes for RGNA09M, as well as the...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop and validate non-contrast MRI methods to assess synovial inflammation (synovitis) in knee osteoarthritis (OA). The $1,472,895 award to The Leland Stanford Junior University will fund the following key efforts over the 5-year project period from April 2024 to February...
This $2,029,684 project grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) aims to define the unique capacity of a miniature joint model (MiniJoint) for investigating the role of adipose tissue and its impacts on osteoarthritis. The University of Pittsburgh is the prime awardee, with a sub-award to Stanford University, to develop the MiniJoint system that...
This $206,023 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is funding research at Cornell University to investigate the mechanotransduction pathways in injured cartilage.
The key objectives are to: 1) Determine how local peak strain magnitudes affect the distribution of cellular phenotypes in cartilage tissue; 2) Investigate how altering...