Project Grant R01AR064186

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to define the systemic mechanisms by which adipose (fat) tissue communicates with the knee joint to drive the development of osteoarthritis (OA). The $1,476,001 award to the Regents of the University of California, San Francisco will fund a comprehensive investigation of three potential interorgan crosstalk pathways: signaling through...

This $426,250 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Minnesota aims to develop an exosome-based therapy for the treatment of osteoarthritis (OA). The project will leverage the immunoregulatory mechanisms present during fetal development to identify multi-tissue organoid-derived exosomes with anti-inflammatory and chondrocyte proliferation potential. Key activities include in vitro studies using human PBMCs to...

This $426,889 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research into the molecular regulatory mechanisms of a cartilage-enriched G protein-coupled receptor (GPCR) named ADGRG6 in maintaining joint homeostasis and preventing osteoarthritis (OA). The research, conducted by the University of Southern California, aims to investigate...

Federal Project Grant Summary WNT Scientific LLC received a $314,363 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 16, 2025, with completion targeted for August 31, 2026. The project focuses on developing an intraarticular injectable disease-modifying osteoarthritis drug (DMOAD) based on Wnt signal inhibition technology....

This $1,024,510 National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases project grant funds research at the University of California, San Francisco into simultaneous imaging of tissue biochemistry and metabolism associated with biomechanics in patellofemoral joint osteoarthritis. The research will conduct a longitudinal cohort study of 100 individuals with isolated patellofemoral joint osteoarthritis followed over two time points. Simultaneous positron...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports the development of a novel pro-angiogenic bone coating hydrogel (ABC Hydrogel) for the treatment of osteonecrosis. The $312,871 award, with a period of performance from May 1, 2025 to April 30, 2030, aims to address the challenges of current osteonecrosis treatments by providing high...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $452,437 to Tufts University School of Medicine to investigate the role of mast cell heterogeneity in the pathogenesis of osteoarthritis (OA). The objective is to uncover the genetic basis and functions of different mast cell subtypes in the OA synovium using advanced proteomics and single-cell RNA sequencing technologies, as well as testing them in a mouse model. The research aims to...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,066,302 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of Massachusetts Medical School (UEI: MQE2JHHJW9Q8) for the period of April 1, 2025 to March 31, 2029. The grant will fund the creation of an OAI Collaborative Osteoarthritis Research Enterprise (OAI CORE) Knowledgebase to extract, accumulate, organize, annotate, and link...

Federal Project Grant Award Summary The University of Connecticut Health Center received a $1,169,596 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded on May 14, 2025, with completion targeted for March 31, 2030. This research project focuses on elucidating the role of NOTCH2 signaling in osteoarthritis pathogenesis and articular inflammation. The...

Federal Grant Award Summary The University of Pennsylvania received a $646,506 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded September 5, 2025, with completion targeted for June 30, 2030. The grant supports the development of dual-action nanoparticle-loaded microparticles designed to treat osteoarthritis by simultaneously addressing multiple...