Project Grant R01AI202795
- The National Institute of Allergy and Infectious Diseases awarded The University of Chicago $810,282 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate combination adjuvants that target trained immunity and the TH1/TH17 immune axis to enhance vaccine efficacy against tuberculosis and other infectious diseases. The research addresses the variable protective efficacy of the currently licensed TB vaccine, Mycobacterium bovis BCG (0–80%...
- The National Institute of Allergy and Infectious Diseases awarded the University of Wisconsin - Madison $717,003 on April 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and assess protective mRNA vaccines against tuberculosis. The project focuses on evaluating the safety, immunogenicity, and protective efficacy of QRNA, a novel mRNA vaccine delivered via QUILA-DOTAP (QTAP), a lipid nanoparticle adjuvant designed for stable mRNA delivery across...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded Beth Israel Deaconess Medical Center, Inc. $1,296,750 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a novel trivalent adjuvanted tuberculosis vaccine. The research will characterize and advance a trivalent TB vaccine candidate consisting of three antigens—PPE20 (RV1387), ESXG (RV0287), and...
- The National Institute of Allergy and Infectious Diseases awarded Seattle Children's Research Institute $1,033,950 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a tuberculosis vaccine regimen optimized to induce lung-resident T cells. The project, titled "A Prime-Pull TB Vaccine Regimen Optimized to Induce Lung-Resident T Cells," focuses on identifying and testing mRNA-lipid nanoparticle vaccine candidates designed to generate...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded $736,079 to the University of Chicago on July 8, 2026, for research investigating the role of commensal-reactive gamma delta T cells in anti-tuberculosis immunity under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project, titled "Role of Commensal-Reactive Gamma Delta T Cells in Anti-Tuberculosis Immunity," examines how specific...
- The National Institute of Allergy and Infectious Diseases awarded $490,704 to the Trustees of Tufts College (doing business as Tufts University School of Medicine) on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop spatial multi-omics methodology predicting granuloma trajectory and bacterial restriction during tuberculosis vaccination. The recipient will use spatial proteomic and transcriptional profiling to map immune cell infiltrates in...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $3,068,770 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop neuraminidase-based influenza vaccines with broad protective immunity. The research systematically analyzes the structure-function relationships of neuraminidase monoclonal antibodies, maps the affinity maturation pathways leading to broadly protective antibodies, and engineers a broadly...
- The National Institute of Allergy and Infectious Diseases awarded the University of Massachusetts Medical School $460,625 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate immune mechanisms underlying BCG vaccine protection against tuberculosis. The research uses Collaborative Cross mouse strains to identify immune signatures associated with vaccine-induced TB protection across genetically diverse host populations. The study focuses on a...
- The National Institute of Allergy and Infectious Diseases awarded Colorado State University $949,073 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop SNAP-TB, a multivalent tuberculosis subunit vaccine candidate for human translation. The funded work, performed in Fort Collins, Colorado, through August 31, 2031, refines a vaccine formulation leveraging the Spontaneous Nanoliposome Antigen Particlization (SNAP) platform to display...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $2.71 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 12, 2025, for research extending through May 31, 2029. This award supports the development and characterization of a novel generation of self-adjuvanted messenger RNA (mRNA) vaccines targeting Mycobacterium tuberculosis (MTB), the causative...
The National Institute of Allergy and Infectious Diseases awarded The University of Chicago $1,229,998 on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a novel TH17-inducing mucosal tuberculosis vaccine. The research advances preclinical development of NETB-EA, a nanoemulsion-based vaccine candidate that delivers immunodominant Mycobacterium tuberculosis antigens (AG85B and ESAT6) via intranasal vaccination to induce T helper type 17 cell responses. The vaccine platform builds on prior in vivo validation showing TB control and decreased TB disease in mice and nonhuman primates, and on Phase I human safety data from an existing nanoemulsion flu vaccine adjuvant (NE01) administered intranasally. The project targets mucosal vaccination as the delivery route, aligned with the natural respiratory tract infection pathway for MTB and designed to preferentially traffic antigen-specific T cells to the airway lumen. Work is performed in Chicago, Illinois with a period of performance through July 31, 2031. The award is classified as a Project Grant, a standard mechanism under NIAID's portfolio for biomedical research in infectious diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/14/26 |