Project Grant R01AI202718
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $849,915 on August 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop mass spectrometry technologies that map post-translational modification (PTM) enzyme-substrate networks during infections. The project will create a suite of proteomics methods to directly connect PTM enzymes to their substrates and modification sites, addressing a critical gap in...
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $448,292 on July 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of ceftazidime-avibactam in combination with meropenem in the prevention and treatment of mutant KPC-producing infections using a hollow fiber infection model. KPC-producing Enterobacterales infections carry mortality rates upwards of 40 percent....
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $853,112 on February 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of pilus-associated proteins PILC1 and PILC2 in Kingella kingae pathogenicity. Kingella kingae is an invasive gram-negative pathogen causing up to 88 percent of bone and joint infections in young children. Performance occurs in Philadelphia, Pennsylvania, from the...
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $906,255 on July 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover and characterize novel genes regulating follicular helper T cell function in antibody responses. The research combines variant-to-gene mapping approaches in human follicular helper T cells to identify disease-associated genetic variation influencing B cell antibody responses. Aim...
- The National Institute of Allergy and Infectious Diseases awarded ST Jude Children's Research Hospital Inc. $335,871 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop precision dosing strategies for beta-lactam antibiotics in immunocompromised children with bloodstream infections. The funded research addresses treatment failure rates exceeding twenty percent in gram-negative bacterial bloodstream infections among pediatric leukemia patients...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pennsylvania $785,766 on July 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R01AI202932) to quantify respiratory and gut bacterial strain persistence and predict pneumonia treatment failure. The recipient will develop a prospective human-subjects cohort called REBEL (Respiratory Bacterial Load) to characterize bacterial load dynamics during and after...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pittsburgh $633,470 on July 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to evaluate primary care telemedicine for managing acute respiratory tract infections in young children. The research addresses unnecessary antibiotic prescribing for pediatric acute respiratory tract infections, where an estimated one-third to one-half of antibiotics prescribed for these conditions in...
- The National Institutes of Health National Heart, Lung, and Blood Institute awarded The Children's Hospital of Philadelphia $360,418 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop integrated host-microbe classifiers for diagnosing lower respiratory tract infection in children using metagenomic next-generation sequencing applied to non-invasive samples including nasopharyngeal swabs and whole blood. The project addresses diagnostic gaps in pediatric...
- The National Institute of Allergy and Infectious Diseases awarded Midwestern University $296,150 on June 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop strategies reducing drug-induced kidney injury from vancomycin, the most widely used hospital antibiotic for methicillin-resistant Staphylococcus aureus. The research defines dynamic toxicity thresholds for vancomycin exposure in the presence of co-nephrotoxins and nephroprotectants across adult...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $489,500 to The Children's Hospital of Philadelphia Research Institute on June 11, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This two-year project, which extends through May 31, 2027, focuses on developing novel sequencing methodologies and analytical pipelines to identify and characterize intact human immunodeficiency virus (HIV) reservoir cells...
The National Institute of Allergy and Infectious Diseases awarded the Children's Hospital of Philadelphia $889,516 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct the Antibiotic Drug Exposures and Endotracheal Pharmacokinetics (DEEP) study. The research aims to understand factors governing antibiotic delivery to the lower respiratory tract in critically ill children, examine how antibiotic concentrations relate to changes in the respiratory tract microbiome and host inflammation in severe bacterial lower respiratory tract infections, and develop optimal antibiotic dosing strategies for pediatric treatment. The Children's Hospital will enroll a subset of participants from an ongoing prospective multicenter cohort study of critically ill children with acute respiratory failure requiring mechanical ventilation, treating participants with cefepime or ceftriaxone with or without vancomycin, and simultaneously quantifying antibiotics in blood and tracheal aspirate samples. Through serial endotracheal sampling, the research team will utilize host and microbe metagenomic analysis to investigate how antibiotic exposures relate to respiratory tract microbiome structure, pathogen eradication, and host inflammation changes. This assistance type is a project grant. The work is performed in Philadelphia, Pennsylvania, with a period of performance extending from August 4, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $889.5k | 8/4/26 |