Project Grant R01AI200393
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of California, Berkeley a Project Grant of $751,663.00 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2031. The award funds research on the dissection of Shigella pathogenesis in vivo utilizing a newly developed oral infection mouse model. Shigella species cause bacillary dysentery, a severe...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of California, San Francisco a Project Grant totaling $717,745 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 12, 2026, with an ultimate completion date of May 31, 2031. This award supports investigator-initiated biomedical research focused on understanding T cell development and immune tolerance mechanisms. The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,202 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, doing business as University of California, Berkeley, with an award date of June 12, 2025 and completion date of May 31, 2027. The grant funds basic immunological research investigating the role of ex-regulatory T cells (exTregs) in...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $201,744.00 to The Regents of the University of California, San Francisco under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 15, 2026. This Project Grant supports fundamental research investigating transcriptional mechanisms that drive dysregulated Type 17 mucosal inflammation via innate lymphoid cells (ILC3s), with direct applications to understanding chronic...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant totaling $156,104 to the University of California, Berkeley under the Allergy and Infectious Diseases Research program (CFDA 93.855) on March 9, 2026, with a completion date of September 7, 2028. This award supports investigator-initiated biomedical research into the protective mechanisms of the gut microbiome against Shigella infection, a globally significant...
- Federal Grant Award Summary The University of California, San Diego received a $3.02 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded July 8, 2025, with a completion date of June 30, 2029. This grant funds basic immunological research investigating the Treg-IL-27 axis in immune regulation, specifically examining how regulatory T (Treg) cells produce interleukin-27 (IL-27) to...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $240,750 to the University of California, Berkeley, under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective May 20, 2026, with completion targeted for April 30, 2028. This award supports research to identify and characterize MELO (Mycobacterial Exporter of Lipids to the Outer Membrane), a novel protein complex responsible for lipid transport in...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $666,065 Project Grant to The Regents of the University of California, San Francisco under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 1, 2026, through May 31, 2031. This five-year research project investigates the molecular mechanisms by which B cells distinguish between self and foreign antigens, with the ultimate objective of developing therapeutic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, San Diego a $3.19 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 16, 2025, with a completion date of June 30, 2029. This grant funds investigator-initiated biomedical research examining the roles and regulation of tissue-resident CD8 T cells during persistent viral infection, utilizing the lymphocytic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, Irvine a Project Grant of $431,750 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period February 1, 2026 through January 31, 2028. This research initiative focuses on investigating the functional expansion of regulatory T (Treg) cells to limit central nervous system (CNS) autoimmunity and promote myelin repair. The research...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of California, Berkeley $787,945 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 11, 2026, for a project period extending through May 31, 2031. The research initiative examines the specificity requirements and functional properties of regulatory T cells (Tregs) that maintain immune tolerance to the microbiota during early life development. The project specifically investigates RORγt+ Tregs generated during the peri-weaning period (approximately postnatal days 14–28 in mice) and their critical role in intestinal tolerance, utilizing gnotobiotic mice colonized with defined microbial communities and an established oral NSAID-induced intestinal inflammation model to assess immune dysregulation and microbiota-specific T cell reactivity. The funded research will deliver scientific knowledge regarding the mechanisms by which early-life microbiota exposure influences lifelong immune tolerance development. Outcomes will include characterization of the distinct functional states of peri-weaning Tregs, identification of specific microbial taxa required for induction of protective immune responses, and development of screening pipelines to assess T cell reactivity patterns. This fundamental immunological research contributes to the broader understanding of microbiota-dependent immune regulation and may inform strategies to prevent or treat immunologic disorders and infectious diseases related to dysregulated intestinal immunity.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $787.9k | 6/11/26 |