Project Grant R01AI198560
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $426,938 effective August 1, 2025 through July 31, 2027 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research focuses on evaluating combined inhibition strategies against Plasmodium falciparum merozoite invasion into erythrocytes, a critical target for antimalarial drug development. The project will assess the...
- The National Institute of Allergy and Infectious Diseases awarded the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. $223,728 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Plasmodium falciparum gametocyte differentiation and adhesion mechanisms as part of Project Grant R21AI199783. The funded research addresses malaria transmission by examining the sexual stage parasites (gametocytes) responsible for...
- The National Institute of Allergy and Infectious Diseases awarded Whitehead Institute for Biomedical Research $899,850 on February 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how apicomplexan parasites recognize and invade host cells. The funded research examines the molecular mechanisms by which parasites such as Toxoplasma and Plasmodium trigger rhoptry discharge—the secretion of proteins from specialized organelles upon contact with host...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $788,379 on June 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research into the adaptive response of Plasmodium falciparum parasites to sickle-trait erythrocytes. The project, titled PARSEC (Plasmodium falciparum Adaptive Response to Sickle Trait Erythrocytes), investigates mechanisms by which sickle-trait hemoglobin confers protection against severe malaria in African...
- The National Institute of Allergy and Infectious Diseases awarded The Pennsylvania State University $247,000 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study mechanisms of translational repression release in Plasmodium parasites during transmission from mammals to mosquito vectors. The research applies reverse genetic, transcriptomic, proteomic, and microscopy-based approaches to determine how malaria parasites control gene expression before and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Maryland, Baltimore $445,488 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period from July 1, 2025 through June 30, 2027. This Project Grant supports scientific research to characterize long non-coding RNAs (lncRNAs) in Plasmodium falciparum and elucidate their roles in gene regulation. The research deliverables include...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded Purdue University $239,023 on August 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop covalent phosphatidylinositol 4-kinase (PI4K) inhibitors targeting malaria parasites. The project executes hit-to-lead optimization of high-priority molecular scaffolds against Plasmodium species that inhibit...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $636,193 Project Grant effective August 25, 2025, through July 31, 2030, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project investigates the interactions between the human gut microbiome and malaria pathogenesis and antimalarial drug pharmacokinetics through integrative multiomics approaches. The study leverages...
- The National Institute of Allergy and Infectious Diseases awarded Weill Medical College of Cornell University $870,131 on August 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define DNA double-strand break repair mechanisms in Plasmodium falciparum and their role in antigenic variation and genome integrity maintenance. The research examines how the malaria parasite repairs DNA damage—specifically double-strand breaks—which the investigator proposes enables...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $816,441 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a longitudinal evaluation of interactions between variable PfEMP1 virulence genes, anti-PfEMP1 antibody repertoires, and outcomes of naturally occurring Plasmodium falciparum infections. The research leverages a cohort of Ugandan children and adults to...
The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $788,453 under Project Grant R01AI198560 on September 2, 2026, to identify essential Plasmodium falciparum determinants of erythrocyte invasion using genome-scale functional genomic approaches. The research will employ a novel transposon-based strategy to map critical genes and molecular pathways underlying red blood cell invasion across multiple P. falciparum strains with distinct phenotypes in invasion, antimalarial drug resistance, continental origin, and transmission. The project will produce a high-confidence map of the essential P. falciparum genome, integrating the results with available omic data to create a research community resource. Performance occurs in Baltimore, Maryland, with a period of performance from September 2, 2026, through August 31, 2031. The funding operates under the Allergy and Infectious Diseases Research program (CFDA 93.855), which supports biomedical research and research training addressing infectious, immunologic, and allergic diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $788.5k | 9/2/26 |