Project Grant R01AI198376
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $476,436 Project Grant to the La Jolla Institute for Immunology on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research initiative, extending through January 31, 2028, focuses on defining the function and regulation of ILRUN, a novel systemic lupus erythematosus (SLE)-susceptibility gene in T cells. The grant supports two primary research...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Leland Stanford Junior University a $127,926 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. This research initiative will characterize autoreactive B cells and their pathogenic roles in Systemic Lupus Erythematosus (SLE) through three integrated research aims: (1) transcriptomic and B cell receptor...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded La Jolla Institute for Immunology a $929,095 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning June 2, 2026, with a completion date of May 31, 2031. This award funds research to advance understanding of lymphoid tissue immunology in systemic lupus erythematosus (SLE) patients and the impact of therapeutic interventions. The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $122,472 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Boston Children's Hospital on August 13, 2025, with a completion date of July 31, 2027. This award supports investigator-initiated research aimed at elucidating the molecular mechanisms underlying the activation and regulation of the NLRP3 inflammasome, a critical component of the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Feinstein Institutes for Medical Research a Project Grant of $209,375 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 23, 2026, with completion scheduled for March 31, 2028. This award funds investigator-initiated biomedical research examining the role of autophagy in B cell tolerance loss, with particular focus on the crosstalk between autophagy...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $124,992 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period May 15, 2026, through April 30, 2028. This award supports investigator-initiated research dissecting the priming and activation mechanisms of the NLRP3 (NOD-like receptor family pyrin domain containing 3) inflammasome in the context of sterile...
- Federal Project Grant Award Summary The University of Pittsburgh received a $499,175 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct genetic and functional dissection of tissue-infiltrating and age-associated B cells in murine lupus models. The five-year award, effective April 1, 2026 through March 31, 2031, will support basic science research aimed at identifying and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant to The Children's Hospital Corporation (Boston Children's Hospital) on July 9, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project, titled "Overcoming Obstacles in Structural Elucidation of B Cell Antigen Receptor Assembly and Lateral Interaction," will be conducted through June 30, 2027, in Massachusetts. The research...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $522,524 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 25, 2025, with a completion date of June 30, 2030. This award supports research into the mechanism of inflammation in adenosine deaminase 2 (ADA2) deficiency (DADA2), a rare inborn error of immunity characterized by systemic inflammation, vascular involvement,...
- Federal Project Grant Summary Award Overview Loyola University of Chicago's Health Sciences Campus received a $423,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on June 25, 2025, with a completion date of May 31, 2027. The research initiative focuses on developing novel antibodies targeting autoreactive B cells as a potential therapeutic intervention for systemic lupus...
Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a $905,875 Project Grant on May 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the genetic mechanisms underlying B cell activation dysregulation in lupus. The research will deliver critical scientific insights through the identification and functional characterization of causal genetic variants associated with lupus risk. Specifically, the project will establish the most likely causal risk variants at two lupus-associated loci, elucidate the mechanisms by which risk alleles cause dysregulation of target genes, and determine the functional roles of these target genes in B cell differentiation. The research will employ advanced methodologies including single-cell profiling, CRISPR gene editing techniques, tonsil organoids, and long-read RNA sequencing to examine both healthy subjects and lupus patients, with the ultimate objective of uncovering new therapeutic targets for treating this autoimmune disease. The five-year project, scheduled for completion on April 30, 2031, is anticipated to yield outputs including published scientific findings on B cell biology mechanisms in the context of chronic autoimmune disease, identification of differential isoform usage driven by lupus risk loci, and prioritized therapeutic intervention strategies. These research deliverables will contribute to the NIAID program's mission of advancing biomedical research addressing infectious diseases and immunologic disorders while potentially reducing disease burden among youth in the United States.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $905.9k | 5/20/26 |