Federal Project Grant Award Summary

Oregon Health & Science University (OHSU) received a $708,281 Project Grant award dated June 17, 2026, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a five-year research initiative (through May 31, 2031) investigating HIV-1 matrix (MA) and envelope (ENV) protein interactions to advance understanding of viral assembly mechanisms and develop improved approaches for combating the AIDS epidemic.

The research products and deliverables will characterize wild-type and mutant MA lattice structures, elucidate MA-ENV protein interactions, and examine interactions between these viral proteins and membrane lipids. The study will clarify how MA and ENV proteins cooperate during infectious virus assembly, illuminate aspects of host cell protein-membrane interactions, and generate findings intended to support the development of novel therapeutic interventions targeting HIV-1 replication mechanisms. OHSU researchers will leverage collaborative expertise and recent preliminary findings to address significant knowledge gaps in HIV-1 pathogenesis, with results expected to contribute to the scientific foundation for new treatment strategies addressing infectious disease and public health concerns.