Project Grant R01AI194920

Award Date 7/3/25
Completion Date 6/30/30
Dollars Obligated $603K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06519, USA
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $859,992 to Yale University to conduct research on the molecular mechanisms underlying HIV-1 maturation and the impact of capsid inhibitors on this process. The research aims to: 1) determine the high-resolution structural pathway of HIV-1 Gag assemblies and capsid during maturation within their native...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $653,693 to Emory University to conduct research on the structural details of HIV-1 virion assembly, maturation, and entry. The work will leverage cryo-electron microscopy and tomography to interrogate the molecular determinants and cellular interactions involved in the HIV-1 capsid lattice formation and...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
This Project Grant award for $1,314,572.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research aimed at developing a cure strategy for HIV-1 using CD4-mimetic compounds (CD4MCs) and CD4-induced antibodies (CD4I Abs). The research, conducted by Yale University, leverages the recent discovery of a new class of indoline CD4MCs that display improved antiviral potency and breadth...
This federal Project Grant award of $2,505,639 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the molecular interactions between lentivirus capsids and the nuclear pore complex protein NUP358. The project aims to investigate how the binding of lentiviral capsids, including HIV-1 and HIV-2, to the RBD4-CHD didomain of NUP358 impacts viral nuclear import and replication....
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,224 to the University of Chicago to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to gain a deeper mechanistic understanding of HIV assembly, maturation, and uncoating processes, with a focus on the roles of viral RNA, host cell factors, and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $769,414 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Iowa. The grant, awarded on July 9, 2025, will support research investigating how the cellular protein SAMHD1 regulates innate immune responses and HIV-1 gene expression in macrophages. The research aims to define the mechanisms by which SAMHD1 suppresses type I interferon induction and NF-kB activation...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $140,733 to The Salk Institute for Biological Studies to conduct structural and biochemical studies on how retroviruses like HIV and MMTV integrate their viral DNA into host chromatin. The research aims to mechanistically interrogate the intasome complex that catalyzes retroviral integration, using novel nucleosome...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $258,200 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant supports research to investigate the non-catalytic functions of HIV-1 integrase (IN) during virion maturation, including developing a biochemical model system to examine IN's ability to encapsulate viral RNA within capsid-like particles and determining cryo-EM structures of IN...
The National Institutes of Health National Institute of Allergy and Infectious Diseases awarded $852,121.24 to The Scripps Research Institute-Florida under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of July 22, 2021 through October 31, 2021. The project aims to identify host factors that regulate HIV latency and reactivation in order to develop strategies for durable HIV silencing. The grantee will define the roles of three identified host factors, P32,...

The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $603,338 Project Grant to Yale University. The grant supports research to understand how the human immunodeficiency virus 1 (HIV-1) mediates fusion with host cells, specifically investigating the interactions between the viral envelope glycoprotein (Env), cellular receptors CD4 and CCR5/CXCR4, and cell membranes. Using cryo-electron tomography and molecular dynamics simulations, the research aims to determine the structural intermediates that drive HIV-1 fusion and the mechanisms by which fusion inhibitors block infection. The project period runs from July 3, 2025 to June 30, 2030.

Generated 8/5/25, 5:24 AM