This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $441,202 to The Regents of the University of California, Berkeley to conduct research on the role of ex-Tregs (ex-regulatory T cells) in autoimmunity and cancer immunity. The goal is to investigate whether ex-Tregs, which arise from regulatory T cells (Tregs), are required to promote anti-cancer immunity and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,428,212 to St. Jude Children's Research Hospital Inc. from July 2025 through June 2029 to conduct research on the "Epigenetic Checkpoint Regulation of Naive T-Cell Quiescence and Peripheral Tolerance". The research aims to understand how intrinsic checkpoint regulators, specifically the ascorbate-TET axis, maintain naive T-cell...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research conducted by the Scripps Research Institute to identify small molecule compounds that can selectively induce the differentiation of functional regulatory T cells (Tregs). The $417,984 award, effective March 7, 2025 through February 28, 2026, aims to: 1) determine the mechanism of action and optimize the...
This Project Grant award of $194,740 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize the development of lung-resident, self-antigen-specific regulatory T cells (Tregs) following acute lung injury. The goal is to understand how these "experienced" Tregs can promote tolerance and prevent future autoimmunity. The principal investigator, Dr. Daniel Shin at...
This $649,053 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research by The Washington University to investigate the role of Ly49 family receptors on CD8 T cells. The central hypothesis is that immunization expands the sub-population of CD8 regulatory T cells (Tregs) that can resolve immune responses, and that Ly49 and the transcription factor Helios...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $571,091 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the role of gut regulatory T (Treg) cells and their interactions with the gut microbiome. The research aims to understand how microbial and food antigens establish gut Treg phenotypes and T cell receptor repertoires, particularly...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $657,673 to the Regents of the University of Minnesota to conduct research on non-deletional CD8+ T cell tolerance. The research aims to define the gene regulation that inhibits self-reactive CD8+ T cells and classify different types of self-reactive CD8+ T cell clones, in order to understand which tolerance...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), will support research on the metabolic and epigenetic regulation of skin regulatory T cells (Tregs) at Emory University. The $597,542 award, spanning March 1, 2025 to February 28, 2030, aims to dissect the specific metabolic program governing the homeostasis of skin Tregs within their tissue microenvironment and...
This $189,540 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to understand the role of apolipoprotein E (APOE) in regulating lymph node stromal cell function and lipid metabolism during autoimmune disease. The research aims to determine how APOE inhibits the suppressive capacity of lymph node stromal cells, known as T cell zone fibroblastic reticular cells (TRCs), and how APOE...