Project Grant R21AI200662
- Federal Grant Award Summary Yale University received a $603,338 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 3, 2025, with a completion date of June 30, 2030. The award supports advanced structural and computational research investigating human immunodeficiency virus 1 (HIV-1) fusion mechanisms on native cell membranes. The primary deliverables include...
- Federal Project Grant Award Summary Yale University received a $483,825 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct structural and mechanistic research on HIV-1 envelope (ENV) neutralization by broadly neutralizing antibodies (BNAbs) targeting the membrane-proximal external region (MPER). The award, effective August 12, 2025 through July 31, 2027, combines cryo-electron...
- Federal Grant Award Summary Yale University received a $453,629 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2025, with completion targeted for June 30, 2027. The grant supports development and application of PHAGE-SEQ, a high-throughput technology combining phage display of nanobodies (VHH recognition domains derived from camelid heavy chain-only immunoglobulins)...
- Federal Grant Award Summary Yale University received a $658,019 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 20, 2025, for performance through July 31, 2030. The R3EDI (Rigorous, Rapid, & Relevant Evidence Adaptation & Implementation) Consultation Hub to EHE (End the HIV Epidemic) will serve as a resource and consultation center leveraging Yale's Center for...
- Federal Project Grant Award Summary Yale University received a $735,631 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2031. The award supports fundamental and translational research investigating the origin, development, and functional properties of a distinct population of CX3CR1+ neutrophils—specialized immune cells that differ from...
- Federal Grant Award Summary Yale University received a $373,090 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 25, 2025, with a completion date of July 31, 2026. The award supports development of Modular Degraders of Extracellular Proteins (MODES), a novel therapeutic approach designed to remove pathogenic extracellular proteins from circulation. The research program...
- Federal Grant Award Summary Yale University received a $3.13 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 25, 2025, with a completion date of June 30, 2029. The grant funds investigator-initiated biomedical research focused on elucidating the mechanisms of lymphoid-specific beta-catenin protein degradation in B-lymphoid cells. The research will characterize how B-cells...
- Federal Grant Award Summary Yale University received a $2.54 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 3, 2025, with completion targeted for August 31, 2029. The award supports fundamental research investigating novel mechanisms of protein homeostasis mediated by the molecular chaperone DnaK, an HSP70 (heat shock protein 70) chaperone in bacterial...
- Federal Grant Award Summary Yale University received a $251,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 2, 2025, with a completion date of August 31, 2027. The grant supports research to identify new antigens in seronegative myasthenia gravis (SNMG), an autoimmune neuromuscular disorder characterized by the absence of detectable autoantibodies to known...
- Federal Project Grant Award Summary Yale University received a $792,513 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 8, 2026, with completion targeted for March 31, 2031. This award supports research investigating serotype re-emergence and vaccine impact in the context of next-generation pneumococcal conjugate vaccines (PCVs). The research will deliver mathematical...
Yale University received a $251,875 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 4, 2026, through April 30, 2028. The project, titled "Exploring the Structural Space Underlying Antibody-Mediated Fc-Effector Functions," will be performed in New Haven, Connecticut. The grant supports research utilizing cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) platforms to elucidate the structural mechanisms enabling antibody Fc-effector functions against HIV-1. Specifically, the research will directly observe how antibody-bound HIV-1 envelope (Env) immune complexes interact with Fc gamma receptors (FcγRs) on plasma membrane blebs and virus-like particles, examining both broadly neutralizing antibodies and other antibody types. The project aims to advance understanding of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) functions, which have emerged as important immune correlates in HIV vaccine efficacy and therapeutic strategies targeting latently infected reservoirs. This research will generate structural data and methodological advances contributing to the scientific knowledge base for improved HIV immunogen design and therapeutic approaches.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $251.9k | 5/5/26 |