Engineering durable immunity by optimizing HIV vaccine parameters to drive long-lived plasma cell development

Active Project Grant Awarded Last action

Award ID
R01AI192456
Recipient
Awarding agency
Obligated
$2,759,908

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 23% complete
Place of performance
La Jolla, CA 92037, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The HIV pandemic has been raging for nearly forty years, and despite immense effort we have yet to discover a vaccine that can induce durable, protective immunity. HIV remains an urgent global health crisis, with 38 million people living with HIV and 1.5 million people newly infected each year. For most infectious diseases but particularly HIV, vaccines are preferable to other forms of prevention or prophylaxis because of their potential durability. Ideally, a single immunization induces protective immunity that lasts for years or even decades. Antibodies are the primary mechanism of protection for nearly all available vaccines, so when considering vaccine durability, an important measure is the length of time that neutralizing antibodies can be maintained at a functional level. In this proposal, we will systematically study the effects of different vaccine parameters on antibody durability. In aim 1, we will evaluate immunogen affinity and valency. In aim 2, we will investigate adjuvants and vaccine platforms, including mrna delivery. In aim 3, we will explore dosing regimens, including promising escalating-dose strategies.

Transactions

Action Obligated Date
Amendment $1,379,954
Original award $1,379,954

Quick answers

Who received award R01AI192456?

R01AI192456 was awarded to Scripps Research Institute by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on August 21, 2025.

How much is award R01AI192456 worth?

$2,759,908 has been obligated on R01AI192456.

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