Project Grant R01AI191109
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $531,245 to Yale University to conduct research on the structure and function of the Salmonella type III secretion sorting platform. Through a multidisciplinary approach, the research aims to investigate the mechanism by which the sorting platform selects and sorts client proteins essential for the pathogenicity of...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the human-adapted Salmonella enterica serovar Typhi (S. Typhi) pathogen activates the Integrated Stress Response (ISR) in host macrophages and how this impacts the innate immune response and infection outcomes. The $173,416 grant, awarded on January 18, 2025, will fund the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
- This Project Grant award of $219,122 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the novel regulation of gene expression in the food-borne pathogen Salmonella typhimurium. The research aims to understand how small regulatory RNAs (sRNAs) interact with the 3' untranslated region of the hild mRNA to control its stability, which in turn regulates the Type 3 Secretion System...
- This federal Project Grant award of $2,727,148.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the interactions between bacteriophages (phages) and the Salmonella pathogen during oxidative stress. The goal is to characterize the mechanisms by which the Salmonella pathogen senses oxidative stress, and how this leads to the activation of phage-derived enzymes that inhibit the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $131,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to systematically understand how evolutionary pressures from the human host and bacteriophages contribute to the genetic diversity of the Salmonella enterica pathogen. Key goals include expanding upon the grantee's established random barcoded transposon...
- This Project Grant award, valued at $102,444, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The goal of the project is to uncover structural insights into the N-terminal core of the SARS-CoV-2 nonstructural protein 1 (NSP1) and establish its specificity in regulating host gene expression, a process known as "host shutoff." This research aims to advance the...
- The University of Utah was awarded a $728,244 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of Salmonella's type III secretion system. The goal is to develop a better understanding of how this critical virulence mechanism in Gram-negative pathogens, including Salmonella, Shigella, Vibrio, Pseudomonas, Yersinia, and Chlamydia, selects...
- This Project Grant award of $145,593 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, supports research at Yale University to study how Helicobacter pylori infection affects the redox regulation of host ribosomal proteins. The research has two key aims: 1) to elucidate whether ribosome biogenesis and translational function are affected during H. pylori infection, and 2) to characterize how the reactivity of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $111,513 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to President and Fellows of Harvard College, doing business as Harvard Medical School, on January 18, 2025. The grant supports research to investigate how gram-positive bacteria use the nucleotide second messenger cyclic-di-AMP to monitor and respond to defects in the cell envelope. The research aims to understand the...
This Project Grant award in the amount of $2,543,522.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to Yale University. The project aims to determine how the molecular chaperone DnaK in the facultative intracellular pathogen Salmonella enterica serovar Typhimurium can directly decrease protein synthesis to enable bacterial survival during cytoplasmic Mg2+ starvation, a relevant infection stress condition. The proposed research will combine genetic, biochemical, and biophysical approaches to solve the structure of DnaK-bound ribosomes and identify the nascent polypeptides associated with DnaK versus the chaperone Trigger Factor during Mg2+ starvation. The findings are expected to provide fundamental knowledge on how bacteria survive during infection by regulating protein synthesis through chaperone activities. The award period runs from September 3, 2025 through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 9/2/25 |