Project Grant R01AI189772
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $197,640 to Massachusetts General Hospital under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 16, 2025, for a five-year project period concluding June 30, 2030. This Project Grant funds investigator-initiated research to advance understanding of sepsis immunopathogenesis through single-cell ribonucleic acid sequencing (scRNA-seq) and functional immunological...
- Federal Grant Award Summary Brigham and Women's Hospital Inc., through its Department of Faulkner Pathology in Boston, Massachusetts, received a $893,459 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, effective April 9, 2026, and extending through March 31, 2031, funds research investigating lipid antigens presented by CD1 molecules to human T cells. The project employs...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $473,937 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 25, 2025, for a project period extending through June 30, 2027. The award supports development of a novel point-of-care liquid biopsy diagnostic tool for early detection of sepsis-associated organ damage. The project leverages the institution's pioneering liquid biopsy...
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Children's Hospital Corporation (Boston Children's Hospital) a Project Grant totaling $489,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 25, 2025, with a completion date of June 30, 2027. This research initiative focuses on characterizing the biological role of αDβ2 as a novel complement receptor in acute lung injury associated with sepsis. The project will...
- FEDERAL PROJECT GRANT AWARD SUMMARY The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $188,916 Project Grant to Brigham & Women's Hospital Inc. (Department of Faulkner Pathology) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, with a completion date of July 31, 2030. This research project investigates how noncytotoxic Staphylococcus aureus evades detection and clearance by the innate immune system, with particular...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $800,557 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 19, 2026, with a completion date of January 31, 2031. This research initiative focuses on identifying mechanisms by which the pathogen Staphylococcus aureus manipulates inflammasome activities critical to host defense. The project addresses a...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $3.08 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 5, 2026, with completion targeted for January 31, 2030. The research will generate scientific knowledge and methodological advances concerning T helper 2 (TH2) cell progenitor populations in chronic type 2 inflammatory...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award funds research investigating neutrophil swarming mechanisms in response to Pseudomonas aeruginosa microcolony aggregates. The research will develop an ex vivo model to elucidate the cellular and molecular...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $135,532 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 20, 2026, with a completion date of March 31, 2028. The award supports investigator-initiated research focused on elucidating lipid transport mechanisms in Mycobacterium tuberculosis (MTB), the leading cause of death from a...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $823,143 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 6, 2026, with performance through January 31, 2031. The project, "Elucidating Treg Defects in ALS," delivers basic biomedical research aimed at identifying mechanisms of dysfunction in regulatory T cells (Tregs) in...
Federal Grant Award Summary Brigham & Women's Hospital Inc., located in Boston, Massachusetts, received a $760,700 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) with an award date of April 6, 2026. The award supports a five-year research project extending through March 31, 2031, investigating the immune regulatory role of reactive oxygen species (ROS) in sepsis pathogenesis and treatment. The project aims to elucidate mechanisms by which ROS modulates interleukin-1 beta (IL-1B) bioactivity in sepsis through ROS-induced oxidation and s-glutathionylation. The research will evaluate combined therapeutic strategies using N-acetylcysteine (NAC) and anakinra (IL-1 receptor antagonist) to develop more effective sepsis treatments. This investigator-initiated biomedical research addresses a critical clinical need, as sepsis and septic shock remain leading causes of morbidity and mortality in intensive care units with limited effective therapeutic options currently available. The research deliverables include scientific findings on ROS regulatory mechanisms and preclinical evidence supporting potential therapeutic interventions for sepsis management.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $760.7k | 4/6/26 |