Project Grant K99AI196044
- Federal Grant Award Summary Brigham and Women's Hospital Inc., through its Department of Faulkner Pathology in Boston, Massachusetts, received a $893,459 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, effective April 9, 2026, and extending through March 31, 2031, funds research investigating lipid antigens presented by CD1 molecules to human T cells. The project employs...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Brigham & Women's Hospital a five-year Project Grant totaling $194,400 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct expanded evaluation of antibody-dependent innate effector function in tuberculosis disease progression among HIV co-infected individuals. The research initiative, which commenced on September 12, 2025 and will conclude on August...
- Federal Project Grant Award Summary Boston Medical Center Corporation received a $711,993 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 11, 2025, with completion targeted for May 31, 2026. This award funds investigator-initiated biomedical research examining the effects of Mycobacterium tuberculosis (MTB) disease on HIV-1 (Human Immunodeficiency Virus) pathogenesis,...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a $798,107 Project Grant on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct tissue-based research examining tuberculosis-associated lung fibrosis and post-TB lung disease (PTLD). The grant, with a completion date of January 31, 2031, supports a collaborative investigation leveraging both a human lung...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston University Medical Campus a Project Grant totaling $245,250 under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 9, 2026 through January 31, 2028. This investigator-initiated research grant supports a two-year study examining the mechanisms of alternative macrophage activation in pulmonary tuberculosis (TB), specifically investigating the phenotypes...
- Federal Grant Award Summary Brigham & Women's Hospital Inc., through its Department of Faulkner Pathology, received a $484,752 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, dated September 23, 2025, with completion by August 31, 2027, funds research investigating the use of chest radiography (CXR) to identify early-stage tuberculosis (TB) in children and youth. The...
- Federal Grant Award Summary Tufts University School of Medicine received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded January 29, 2026, with completion targeted for August 15, 2028. The award funds research to elucidate spatio-temporal innate immune cell modulation of Mycobacterium tuberculosis (MTB) stress response and replication heterogeneity. The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts Medical School a Project Grant totaling $832,076 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, with a completion date of July 31, 2030. This research initiative focuses on characterizing protective CD8 T cell responses to Mycobacterium tuberculosis (MTB) infection, with the ultimate objective of informing...
- Federal Project Grant Summary Boston Medical Center Corporation received a $872,596 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2031. The award supports investigator-initiated biomedical research examining HIV-1 (Human Immunodeficiency Virus) antibody responses and pathogenesis in people living with HIV who have concurrent tuberculosis...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $104,262 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on September 30, 2025, with a completion date of May 31, 2028. This research project, "Linking Mycobacterium tuberculosis Infection Outcomes with Transcriptional Networks in Genetically Diverse Mouse Macrophages," will advance...
Brigham & Women's Hospital Inc. received a $135,532 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 20, 2026, with a completion date of March 31, 2028. The award supports investigator-initiated research focused on elucidating lipid transport mechanisms in Mycobacterium tuberculosis (MTB), the leading cause of death from a single pathogen worldwide. The research deliverables include the characterization of lipid transport pathways across mycobacterial membranes using advanced lipidomic and mass spectrometry methodologies, identification of the roles of the MCE4 lipid transport system in maintaining steady-state levels of native mycobacterial lipids, and determination of novel lipoglycan transport mechanisms involving the lipid mannosyl phosphomycoketide (MPM) and its associated glycans. The funded research will advance scientific understanding of how MTB controls the localization and biological effects of lipidic antigens and virulence factors through comprehensive analysis of lipid transport in both laboratory and clinical strains. Deliverables encompass mechanistic studies employing reverse micelle separation techniques, chromatography, electron microscopy, and glycan labeling to uncover previously undiscovered transport pathways and establish the in vivo essentiality of the PKS12 gene in human tuberculosis disease, thereby contributing to potential therapeutic targets for infectious disease intervention.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $135.5k | 4/21/26 |