Project Grant R01AI189723
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) provides $189,713 to Northwestern University to conduct research on the role of the PIM1 kinase in regulating the metabolic adaptation of CD8 effector T cells during chronic viral infections. The research aims to elucidate the IL-21-PIM1 signaling axis and its impact on the differentiation and function of late-stage...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,486 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Johns Hopkins University. The purpose of this 20-month grant, with a period of performance from September 2025 to April 2027, is to identify metabolic targets that could reinvigorate exhausted T cells and enhance their function against viruses, bacteria, and tumors. The research aims to elucidate how chronic T cell...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $743,752 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Utah. The grant will support research to define how chronic antigen stimulation contributes to epigenetic programming that drives dysfunction in virus-specific CD4+ T cells during chronic viral infection. The project aims to use highly innovative in vivo models and whole genome DNA methylation sequencing...
- This $162,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to investigate the mechanisms that maintain the longevity and functional diversity of memory CD8+ T cells in both circulating and tissue-resident populations. The research aims to elucidate how these memory T cell subsets are regulated by cytokines during homeostasis and in response to...
- This $1,269,762 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports the development and optimization of a new microfluidic platform called SECRE (Secretion-Enabled Cell Ranking and Enrichment) for high-performance sorting of immune cells based on their distinct secretion patterns. The goal is to leverage this technology to conduct genome-wide CRISPR activation and/or knockout screening to identify...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) provides $156,160 to Northwestern University to study the structural basis of HIV accessory proteins VPR and VIF. The goal is to contribute to understanding and potentially combating the HIV/AIDS pandemic through structural biology research. The award period runs from September 1, 2025 to August 31, 2027. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $240,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Northwestern University to conduct research on characterizing the HIV-1 viral reservoirs that persist even under antiretroviral therapy (ART). The 2-year project aims to identify the cellular sources and genetic diversity of the HIV-1 reservoirs, as well as study the sources and characteristics of the residual viremia...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $807,799 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the University of Chicago. The grant, which runs from Jul 15, 2025 to Jun 30, 2030, supports research to investigate the role of a specialized subset of regulatory T cells in controlling self-reactive B cells and the production of autoantibodies. The research aims to identify these B cell-dependent...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $1,135,986 Project Grant to Northwestern University. The grant, effective January 1, 2025, aims to identify cellular and molecular targets for developing tissue/cell-specific strategies to prevent cytomegalovirus (CMV) reactivation and improve outcomes in kidney transplant recipients. The research will investigate the role of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $627,462 to Northwestern University to conduct research on T cell exhaustion in chronic viral infections. The key objectives are to leverage single-cell RNA sequencing and paired TCR sequencing technologies to lineage trace the ancestors of effector and exhausted T cell subsets, and explore how TCR signaling strength and cross-presenting dendritic cells (cDC1s) influence the differentiation of these subsets. This research aims to uncover new opportunities for therapeutic interventions to treat infectious diseases. The award has an initial performance period from August 7, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $627.5k | 8/7/25 |