Project Grant R01AI189606
Award Date
5/2/25
Completion Date
4/30/30
Dollars Obligated
$390K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Colorado, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $189,150 to investigate the molecular mechanisms of the HtrA enzyme in the pathogenic bacterium Streptococcus pneumoniae. The research aims to elucidate the structural rearrangements and dynamics of the HtrA monomer, as well as the structural basis of HtrA oligomerization and substrate engagement. Led by the University of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $948,482 to the University of Colorado-Denver to study the molecular mechanisms of the YbtPQ siderophore importer in antibiotic-resistant bacterial infections. The 5-year award, beginning on July 17, 2024, aims to define the substrate selectivity and inhibitory mechanisms of YbtPQ, as well as understand its...
This Project Grant award, identified as R21AI188434, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The $226,253 award will fund research conducted by The Washington University in Missouri to investigate how the host protein ADAM10 modulates the interaction between neutrophils and the endothelium during Staphylococcus aureus infection. The goal of this research is to gain a mechanistic...
This federal Project Grant award, valued at $267,310.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to evaluate the role of a lipoic acid transfer protein in the metabolism and virulence of Staphylococcus aureus. The key objectives of this project are to: 1) Determine how the lipoic acid transfer protein (LipL) interfaces with the phosphotransacetylase (Pta) enzyme to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $236,100 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Georgia Tech Research Corp to characterize two virulence-associated small RNAs (sRNAs) in Staphylococcus aureus (S. aureus). The research aims to elucidate the mechanisms controlling expression of the sRNAs, identify their regulatory targets, and assess their importance for S. aureus virulence using a murine surgical wound infection model....
The federal Project Grant award R03AI185538 is being provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $148,200 award will fund research to explore the structural and functional characteristics of the 5'-GUAC- RNA motif, which has been found to exhibit unique conformational properties in various biological contexts such as viral RNA, miRNA, and tRNA. The research aims to elucidate the nature...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to characterize the production and biological effects of Staphylococcus aureus extracellular membrane vesicles (MVs) in vivo during bacterial infection. The total award amount is $946,912.00, with a project period from May 22, 2024 to March 31, 2026. The key objectives of this research project are to: 1)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $569,210 to the University of Colorado Boulder to conduct research on mechanisms of lipid A modification that contribute to antimicrobial resistance. The research aims to structurally and functionally characterize three key proteins responsible for cationic antimicrobial peptide (CAMP) and colistin resistance in...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop novel antibiotic drug candidates that target the Suf-like pathway of iron-sulfur cluster biosynthesis as a treatment for drug-resistant infections caused by Gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Streptococcus pneumoniae. The total awarded amount is...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $840,462.15 to Mississippi State University to conduct research on the structure, orientation, and competitive interactions of Staphylococcus epidermidis biofilm proteins on medically relevant surfaces. The key objectives are to: 1) establish biophysical rules for how S. epidermidis proteins bind to...