Project Grant K08AI182476

Award Date 1/9/25
Completion Date 12/31/29
Dollars Obligated $185K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
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The grant supports research and career development activities focused on evaluating the potential of mRNA-lipid nanoparticle (mRNA-LNP) platforms and lipid nanoparticle (LNP) adjuvants to overcome maternal antibody interference, which has been a major barrier to effective early-life immunization against diseases like influenza and measles. The research aims to determine the mechanisms by which mRNA-LNP and LNP-adjuvanted vaccines can overcome maternal antibody interference, as well as assess whether these properties could be broadly applied to other vaccine types. The findings are expected to inform new approaches to vaccine and adjuvant development to improve protective immune responses in newborns and young infants.

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