This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $184,896 to The Children's Hospital of Philadelphia (CHOP) over the period of Jan 9, 2025 to Dec 31, 2029. The grant supports research and career development activities focused on evaluating the potential of mRNA-lipid nanoparticle (mRNA-LNP) platforms and lipid nanoparticle (LNP) adjuvants to overcome maternal antibody interference, which has been a major barrier to effective early-life immunization against diseases like influenza and measles. The research aims to determine the mechanisms by which mRNA-LNP and LNP-adjuvanted vaccines can overcome maternal antibody interference, as well as assess whether these properties could be broadly applied to other vaccine types. The findings are expected to inform new approaches to vaccine and adjuvant development to improve protective immune responses in newborns and young infants.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $184.9k | 1/9/25 |