The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $637,729 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to President and Fellows of Harvard College (Harvard Medical School) to investigate the molecular mechanisms underlying the activation and regulation of essential bacterial cell wall synthase enzymes. The research aims to develop a detailed mechanistic understanding of these enzymes, which are critical for bacterial growth and potential antibiotic targets. The 5-year project, running from December 2024 to November 2029, will employ a combination of structural biology and single-molecule fluorescence approaches to elucidate how accessory partners regulate the activity of two orthogonal families of peptidoglycan synthases in bacteria. This work is expected to pave the way for future antibiotic discovery efforts targeting these essential enzymes.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $637.7k | 12/13/24 |