Project Grant R01AI189552

The federal Project Grant award R01AI189552, totaling $729,006.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). This grant supports research to investigate how the adenovirus manipulates host RNA binding proteins (RBPs) to exploit cellular RNA processing pathways and overcome host defenses. The research aims to define the mechanisms by which modulation of RBP methylation promotes adenovirus infection through changes to splicing and RNA processing, as well as examine viral evasion of cytoplasmic granules and the impact of manipulating host responses. The award is held by the Children's Hospital of Philadelphia Research Institute, a leading pediatric medical research institution, and the research will employ innovative technologies to study changes in RNA-protein complexes mediated by RBP modification during adenovirus infection. The findings from this project are expected to provide fundamental knowledge of virus-host interactions and identify potential new antiviral therapeutic targets.