Project Grant R01AI189389

Award Date 8/1/25
Completion Date 7/31/30
Dollars Obligated $464K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $464,296.00 to the University of Wisconsin - Madison to study the impact of bat hibernation on metabolism and immunity to Pseudogymnoascus destructans (PD) fungal infection.

The key goals are to define how temperature changes during bat hibernation affect the metabolism and immune functions of bat keratinocytes and neutrophils, and how these temperature-induced metabolic changes impact the immune response to PD infection. The researchers will use a novel bat hibernation model and 3D organotypic platforms to investigate the underlying mechanisms linking temperature, metabolism, and immunity. Findings from this 5-year project are expected to provide new insights into how hibernation uniquely affects bat immunity to infectious diseases.

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