Project Grant R01AI189285

This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,657,972.00 to the Oregon Health & Science University (OHSU) to conduct research aimed at characterizing allogeneic T cell responses that mediate HIV cure in individuals who have undergone allogeneic hematopoietic stem cell transplantation (alloSCT).

The key objectives of this 5-year project are to: 1) Define the allogeneic T cell responses and their targets in individuals cured of HIV following alloSCT; 2) Characterize the allogeneic T cell responses and their targets in SIV-infected Mauritian cynomolgus macaques (MCM) cured of SIV after alloSCT; and 3) Adoptively transfer allogeneic T cells expressing human or MCM T cell receptors into HIV-positive humanized mice or SIV-positive MCM to assess the safety and efficacy of allogeneic T cells for HIV cure. This research aims to expand the understanding of the mechanism of HIV cure in the setting of allogeneic HSCT and establish a new therapeutic approach for achieving an HIV cure.