Project Grant R01AI187162

Award Date 6/4/25
Completion Date 5/31/30
Dollars Obligated $800K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Georgia, USA
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  1. Comprehensive testing of the effects of IL-15/IL-15RA-FC therapy combined with TGF-beta blockade (Galunisertib) on different T and NK cell subsets during chronic SIV infection under antiretroviral therapy (ART) (Aim 1).

  2. Investigation of how the changes in T and NK cell function affect viral reservoirs under ART and viral control after ART interruption (Aim 2).

  3. Combination of the optimal cytokine therapy with vaccination to further enhance the magnitude and breadth of SIV-specific CD8 T cell responses, with the goal of improving the therapeutic benefit (Aim 3).

The award will be performed by Emory University, a private research university in Atlanta, Georgia, over the period of June 4, 2025 to May 31, 2030.

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