Project Grant R01AI188710

Award Date 7/8/25
Completion Date 6/30/29
Dollars Obligated $3M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,194,992 to the University of California, San Diego (UC San Diego) to conduct research on the roles and regulation of tissue-resident CD8 T cells during a persistent viral infection. The key objectives are to: (1) evaluate the role of tissue-resident CD8 T cells in intestinal hyper-permeability and colitis during a sustained viral...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the immunological changes that occur in the ileal pouch of ulcerative colitis patients who develop pouchitis compared to those who do not. The $409,320 award to the University of California, San Diego will apply single-cell RNA sequencing and spatial transcriptomics to identify potential...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $571,091 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the role of gut regulatory T (Treg) cells and their interactions with the gut microbiome. The research aims to understand how microbial and food antigens establish gut Treg phenotypes and T cell receptor repertoires, particularly...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $441,202 to The Regents of the University of California, Berkeley to conduct research on the role of ex-Tregs (ex-regulatory T cells) in autoimmunity and cancer immunity. The goal is to investigate whether ex-Tregs, which arise from regulatory T cells (Tregs), are required to promote anti-cancer immunity and...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute in La Jolla, CA to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The researchers will employ chemical biology and proteomics methods to identify specific microbiota-associated bile acid protein targets in mammalian cells...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research conducted by the Scripps Research Institute to identify small molecule compounds that can selectively induce the differentiation of functional regulatory T cells (Tregs). The $417,984 award, effective March 7, 2025 through February 28, 2026, aims to: 1) determine the mechanism of action and optimize the...
This $567,962 project grant from the National Institutes of Health National Institute of Allergy and Infectious Diseases will fund research at the University of Alabama at Birmingham from March 2022 to February 2027 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant will support research into the coordination of innate and adaptive immunity in intestinal barrier defense. Specifically, the grantee will define the mechanisms by which innate and adaptive immune...
This Project Grant award of $438,500 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of California, San Diego (UCSD) to investigate the mechanisms regulating immunoglobulin gene rearrangement. The research aims to determine how enhancers and epigenetic modifications orchestrate chromatin dynamics and spatial confinement to enrich interactions between variable...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how exposure to food antigens leads to the formation of regulatory T cells and hyporesponsive conventional T cells in the gut. The $553,342 award to the Regents of the University of Minnesota will be used to study the underlying mechanisms, with the goal of identifying potential therapies for...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,022,197 to the University of California, San Diego (UCSD) to study the role of regulatory T (Treg) cells and the IL-27 cytokine in maintaining intestinal immune homeostasis. The research aims to examine the molecular mechanisms driving IL-27 expression in gut Treg cells, as well as identify gut microbiome factors that contribute to this process, particularly under inflammatory conditions. The award period runs from July 8, 2025 through June 30, 2029. The findings from this comprehensive research project are expected to advance the fundamental understanding of tissue-specific Treg cell regulation and provide insights into potential therapeutic approaches for inflammatory bowel disorders.

Generated 8/5/25, 6:41 AM