Project Grant R01AI187588
- This Project Grant award of $384,363.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Temple University in Philadelphia, PA. The goal of the research is to study the role of the PELLINO1 (PELI1) protein in regulating antiviral immunity in the skin epidermis, with a focus on herpes simplex virus infections. The researchers will use mouse models and human/mouse cell cultures to define...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $769,366 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant, effective from February 1, 2025 to January 31, 2030, aims to decipher the ontogeny of CD4+ resident memory T cells that globally seed the skin and protect against cutaneous leishmaniasis. The...
- This $2,483,910 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research at The Washington University to investigate novel genetic mechanisms underlying primary immune regulation disorders (PIRD). Specifically, the research aims to: 1) Map genes prone to autosomal random monoallelic expression (ARMAE) in the immune system and define epigenetic marks governing this process, validating findings in...
- This $250,396 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify differences in DNA regulatory elements that control gene expression in skin cells from individuals of different ancestral backgrounds. The research team at the Icahn School of Medicine at Mount Sinai will utilize advanced genomic techniques, including...
- This $256,808 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to better define the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The University of Washington is conducting this research, which focuses on analyzing altered mRNA splicing in SLE neutrophils and exploring the consequences of these splicing changes, including...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $132,677 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on mapping genetic variants associated with inflammatory bowel disease (IBD) to their target genes and functional effects in human macrophages. The project aims to elucidate the transcriptional consequences of IBD candidate genes in monocytes and...
- The University of California, Davis received a $126,738 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on May 29, 2025. The grant supports research to investigate extramedullary granulopoiesis and immune responses in human skin using a novel skin-on-a-chip model. The project aims to provide mechanistic insight into the migration of hematopoietic stem and progenitor cells into human skin and their role in...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $800,005 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the structural basis and functional impacts of genetic variants in G-protein coupled receptors (GPCRs) associated with autoimmune diseases. The project aims to: 1) define the structural basis for impaired...
- This Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to define and treat genetic abnormalities in overlapping rashes of psoriasis and atopic dermatitis (termed "PSO-AD"). The $628,968 award to the University of California, San Francisco will leverage innovative biomarker techniques, including spatial transcriptomics and...
- This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), will support research into the crosstalk between immune dysregulation and impaired wound healing in a severe, systemic autoinflammatory disease called disabling pansclerotic morphea (DPM). The $385,575 award to the University of California, San Diego (UCSD) will fund a 5-year investigation into the role of...
This $778,934 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to decipher the genetic susceptibility of pemphigus, a rare and potentially life-threatening autoimmune skin disease. The lead institution, University of North Carolina at Charlotte, will apply a multi-omics approach to precisely map the extended major histocompatibility complex (MHC) variation and its genetic associations in pemphigus. This includes long-read sequencing of the extended MHC, single-cell RNA sequencing to analyze expression profiles and perform expression quantitative trait loci (eQTL) mapping, and massively parallel phage sequencing to measure antibody responses and identify novel autoantigens. The goal is to reveal MHC genetic variants that affect gene expression and functionally demonstrate disease mechanisms, which could inform new treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $778.9k | 7/28/25 |