The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, has been awarded a Project Grant of $769,366 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). This 5-year grant will fund research to decipher the development and maintenance of CD4+ resident memory T cells in the skin, which can provide long-lasting protection against vector-borne pathogens such as Leishmania major. The research aims to identify the factors required for expanding this protective T cell population, including the role of the skin microbiome and T cell intrinsic signals. These findings could lead to more effective vaccines for leishmaniasis and other vector-borne diseases that lack viable preventative options.
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