This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $232,073 to investigate host-pathogen dynamics in microglia during co-infection with Cryptococcus neoformans (CN) and HIV. The research aims to explore the impact of CN replicative aging on its survival and virulence in the central nervous system of AIDS patients. Specifically, the study will examine how aged...
This $616,588 Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to illuminate environmental sensing mechanisms in the fungal pathogen Cryptococcus neoformans, which causes deadly fungal meningitis. The award recipient, The Regents of the University of California, San Francisco (UCSF), will utilize a high-precision phenotypic profiling method to map genetic...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $749,594 to study the role of the host sphingosine kinase 1 (SK1) pathway in controlling Cryptococcus neoformans infection during immunodeficiency. The awardee, The Research Foundation For The State University Of New York (Stony Brook University), will use a mouse model to investigate how the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $665,171 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Regents of the University of Minnesota. The 5-year grant, awarded on August 18, 2024, aims to improve understanding of drug exposure in the brain and cerebrospinal fluid (CSF) to optimize treatment for HIV-associated opportunistic infections like cryptococcal and TB...
This Project Grant award of $2,366,783.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to determine the molecular processes by which infectious spores of the fungus Cryptococcus transition into vegetatively growing yeast (germinate) and how this process influences disease. The overarching goal is to gain a better understanding of the fundamental biology of pathogenic fungi,...
This $443,944.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research by the University of Georgia Research Foundation to study the genetic basis of two key pathogenesis traits in the fungal genus Cryptococcus - thermotolerance and azole drug resistance. The research aims to employ high-throughput genetic approaches to characterize how genome-wide factors...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $186,451.00 to the University of Maryland, College Park to conduct research on characterizing the molecular mechanism of CD4+ T cell migration to the brain during HIV/AIDS-associated cryptococcal immune reconstitution inflammatory syndrome (IRIS). The key objectives of the research are to determine whether...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $773,053 Project Grant to The Washington University in St. Louis to conduct research on the synthesis and role of beta-1,6-glucan in the cell wall of the fungal pathogen Cryptococcus neoformans. The goal of this 5-year project is to define the biosynthesis of beta-1,6-glucan, a key component of the Cryptococcus cell wall, in order to better...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,668,032.00 to the University of Pittsburgh to conduct research into the mechanisms of HIV-1 latency in the central nervous system (CNS). The primary objectives are to identify key factors, pathways, and regulators that control the establishment, maintenance, and reactivation of latent HIV-1 reservoirs in CNS myeloid cell lineages,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,797,623 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, San Francisco (UCSF) to decipher the significance of pathogen genetic variation and evolution. The 5-year research project, which commenced on July 8, 2024, will use a combination of genetics and experimental evolution to understand complex epistasis with respect to genetic...