This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $884,322 to the Fred Hutchinson Cancer Center to study the mechanisms that create and sustain the HIV reservoir, a population of latently infected cells that persists during HIV treatment and prevents a cure.
The research team, led by Dr. Reeves, will use a mathematical modeling approach to integrate existing and new experimental data on HIV viral loads, genetic sequences, and immune cell characteristics across different stages of infection - including early/chronic untreated infection and early/long-term treated infection with analytical treatment interruptions. This work aims to determine the key mechanisms driving HIV reservoir creation, maintenance, and evolution, in order to inform the development of therapeutics towards an HIV cure. The project will involve collaboration with researchers at The Johns Hopkins University, who will provide expertise and data to support the modeling efforts.
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