Project Grant R01AI184963
- This federal Project Grant award, with a total funding of $642,056, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to characterize plasma cell infiltrates in cardiac allograft vasculopathy (CAV), a leading cause of morbidity and mortality after heart transplantation. The key objectives are to: 1) characterize the clonal composition and transcriptome profile...
- This federal Project Grant award of $246,750 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a research study on the "Transcriptional and Functional Identity of Human T Follicular Helper Cells Across Tissues". The project aims to conduct a systematic analysis of human T follicular helper (Tfh) cells across lymphoid and mucosal tissues, including the lung, in order to define how T cells influence...
- The federal Project Grant award of $231,552 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of intrahepatic (liver-resident) plasma cells in clearing hepatitis C virus (HCV) infection. The project aims to determine the mechanistic origins of these liver-resident plasma cells during acute HepaCViral infection, with the goal of identifying specific prerequisites...
- This federal Project Grant award, valued at $459,439.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research aimed at improving the understanding of alloreactivity, the immune response that leads to acute cellular rejection of transplanted tissues. The research seeks to identify the specific peptide-HLA complexes recognized by alloreactive T cells, which could...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,135 to develop a new magnetics-based method for rapidly mapping the mechanical properties of tissues. The goal is to address technical limitations of current scanning probe methods used to study the tumor microenvironment and its impact on T cell function in solid tumors. The award will fund the development and...
- This $858,186 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project titled "Decoding T Cell Clonotypes, Biology and Predictive Biomarkers Associated with Immune Checkpoint Myocarditis." The project aims to investigate the mechanisms underlying immune-related myocarditis, a potentially fatal adverse event associated with immune checkpoint inhibitor cancer therapies. Using...
- This Project Grant award of $239,348.00, granted by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), is funding research to investigate a newly identified population of CD1a-restricted T cells that respond to the lipid antigen phosphatidylglycerol (PG). The research aims to determine under what (patho)physiological conditions mitochondrial PG becomes visible to these T cells, including during mitophagy, induction of...
- This federal Project Grant award of $1,442,898.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to study the effects of vaccination on outcomes of acute and post-acute respiratory viral infections, including COVID-19, in solid organ transplant recipients. The research aims to better understand the risks of severe respiratory viral infections and associated post-acute syndromes...
- This Project Grant award for $1,063,324 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on CD4+ T cell immunity in the respiratory tract, with a focus on understanding the mechanisms underlying host defense against extracellular pathogens, particularly in the area of Type 17 cytokines and tissue resident memory CD4+ T cells. The research will utilize murine and primate respiratory tract samples to assess the metabolic...
- This $162,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to characterize the role of plasmacytoid dendritic cells (PDCs) in Mycobacterium tuberculosis (MTB) infection. The research aims to quantify PDC trafficking and activation in the lungs during MTB infection, and determine how PDC-driven type I interferon responses impact MTB control. The project will leverage a mouse model that...
This federal Project Grant award of $761,840, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research to characterize plasma cell infiltrates in cardiac allograft vasculopathy (CAV), a leading cause of morbidity and mortality after heart transplantation. The key objectives are to use advanced immunoglobulin gene repertoire analysis and single-cell RNA sequencing to comprehensively profile the plasma cells infiltrating cardiac allografts during CAV, and to evaluate the functional properties and pathogenicity of the antibodies produced by these intragraft plasma cells. The award was granted on August 5, 2025, with an ultimate completion date of July 31, 2030. The research is being conducted by The Trustees of Columbia University in the City of New York, which has extensive expertise in biomedical research and a strong track record of federal contract and grant awards supporting critical initiatives across multiple health domains.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $761.8k | 8/5/25 |