Project Grant R01AI184551
- This five-year, $813,838 project grant from the National Institute of Allergy and Infectious Diseases will fund research into the genetic and hormonal mechanisms underlying sex differences in tuberculosis (TB) and TB-HIV coinfection. The Johns Hopkins University will investigate how X chromosome complement and sex steroid hormones impact TB pathogenesis using cellular models, animal studies, and human samples. Researchers will utilize a novel four core genotype mouse model to differentiate the...
- The University of Arkansas for Medical Sciences received a $450,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded August 1, 2025, with completion by July 31, 2027. This research project will conduct single-cell spatial-temporal analysis to understand how different macrophage subsets maintain lesion biology and influence local Mycobacterium tuberculosis (MTB) infection outcomes....
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $3.1 million Project Grant on September 19, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a four-year research initiative examining macrophage senescence as a driver of granuloma failure and progression to necrosis in tuberculosis and TB/HIV co-infection. The research will be conducted in Baltimore, Maryland, with...
- Grant Award Summary Case Western Reserve University received a $813,450 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2030. The research project focuses on evaluating human T cell responses specific for Mycobacterium tuberculosis (MTB) antigens that are processed and presented by infected macrophages. The research builds on...
- Federal Project Grant Award Summary The University of Massachusetts Medical School (UMMS) received a $104,262 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 30, 2025, with a completion date of May 31, 2028. The research project, titled "Linking Mycobacterium Tuberculosis Infection Outcomes with Transcriptional Networks in Genetically Diverse Mouse...
- The University of Pittsburgh received a $2.32M Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 24, 2025, with completion targeted for March 31, 2030. This grant supports research to optimize oral Bacille Calmette-Guérin (BCG) vaccination as a more effective tuberculosis preventive intervention. The project encompasses three primary research objectives: optimizing an oral BCG...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $819,998 to The Regents of the University of California, San Francisco on July 16, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports a five-year research initiative (completion date: May 31, 2030) to identify and characterize host cell death factors during Mycobacterium tuberculosis (MTB) infection using proteomics and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $427,623 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research examining how HIV-induced immunometabolic perturbation impairs tuberculosis (TB) control. The award, obligated on February 24, 2026, with completion scheduled for January 31, 2028, supports investigator-initiated research that dissects the...
- Federal Grant Award Summary Tufts University School of Medicine received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded January 29, 2026, with completion targeted for August 15, 2028. The award supports research to elucidate spatio-temporal innate immune cell modulation of Mycobacterium tuberculosis (MTB) stress response and replication heterogeneity. The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston University Medical Campus $245,250 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 9, 2026, with a completion date of January 31, 2028. This Project Grant supports fundamental research investigating the mechanisms of alternative macrophage activation in pulmonary tuberculosis (TB), specifically examining the phenotypes and development of...
SIRTUIN -DEPENDENT REGULATION OF TUBERCULOSIS AND HIV INTERACTIONS IN MACROPHAGES - ABSTRACT TUBERCULOSIS CONTINUES TO KILL ABOUT 1 MILLION PEOPLE INCLUDING CHILDREN EACH YEAR WITH 8 MILLION NEW CASES. REGRETTABLY, COINFECTION WITH HIV-1 HAS AGGRAVATED THE PROBLEM BECAUSE HIV-1 DEPLETES CD4 T CELLS, WHICH ARE THE MAIN DEFENSE MECHANISM AGAINST TUBERCULOSIS. FOR THE REASON, BCG, WHICH IS A LIVE ATTENUATED VACCINE AGAINST TUBERCULOSIS, CANNOT BE GIVEN TO PEOPLE LIVING WITH HIV. WE RECENTLY DISCOVERED THAT SIRTUIN TYPE OF PROTEIN AND HISTONE DEACETYLATES PLAY A MAJOR ROLE IN REGULATING THE GROWTH OF BOTH M. TUBERCULOSIS AND HIV-1 IN HUMAN MACROPHAGES AND DRUG TARGETING SIRTUINS COULD CONTROL BOTH PATHOGENS IN CELL CULTURE MODELS AND IN HUMANIZED MICE. THEREFORE, WE PROPOSE TO INVESTIGATE SIRTUIN-DEPENDENT INTERVENTION TO UNDERSTAND HOW TB AND HIV-1 INFECTIONS INDUCE THESE ENZYMES AND HOW WE CAN DEVELOP NOVEL IMMUNOCHEMOTHERAPY FOR CONFECTIONS. SPECIFICALLY: AIM-1: WE WILL ANALYZE THE IMPACT OF EARLY MTB AND HIV INFECTION ON SIRTUIN GENE AND PROTEIN INDUCTION IN MACROPHAGES AND IDENTIFY THEIR EPIGENETIC TARGETS. WE WILL EXAMINE THE HYPOTHESIS THAT MTB-INDUCED SIRTUIN-2 CAN AUGMENT HIV-1 REPLICATION, WHEREAS HIV-1 INDUCED SIRTUIN-2, IN TURN ENHANCES MTB GROWTH IN MFS THEREBY AGGRAVATING COINFECTIONS. WE WILL THEN DEVELOP AN IMMUNOCHEMOTHERAPY (ICT) USING A COMBINATION OF SIRTUIN DRUGS, TB AND HIV TARGETING DRUGS TO KILL AND ERADICATE BOTH HIV-1 AND M. TUBERCULOSIS IN MACROPHAGES. AIM-2: WE WILL INVESTIGATE THE EFFECT OF SIRTUIN DRUGS ON EARLY AND LATE STAGES OF TB-HIV-1 COINFECTION USING HUMANIZED MICE AND DETERMINE WHETHER ICT CAN ERADICATE CONFECTIONS. AIM-3: TUBERCULOSIS GRANULOMAS CAN RESTRICT GROWTH OF M. TUBERCULOSIS PATHOGEN, ALTHOUGH PRIOR INFECTION WITH HIV-1 CAN DEPLETE CD4 T CELLS AND AFFECT GRANULOMA FORMATION. WE WILL USE A TB-HIV COINFECTION MODEL OF HUMANIZED MICE TO DETERMINE IF SIRTUIN-DRUG THERAPY CAN ACTIVATE MACROPHAGES OF GRANULOMAS AND INCREASE HOST-DEFENSE AGAINST TUBERCULOSIS. OUR OVERALL GOAL IS TO DEVELOP INNOVATIVE IMMUNE DEFENSE-BASED INTERVENTION METHODS TO ERADICATE TB-HIV COINFECTIONS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 7/2/25 | ||
| Not listed | $1.3m | 7/29/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
AGMT00013852S | Baylor College Of Medicine | Project Grant R01AI184551 | $144.0k | 1/13/25 | |
AGMT00013854S | University Of Texas Medical Branch At Galveston | Project Grant R01AI184551 | $143.1k | 10/4/24 | |
AGMT00013853S | University Of Texas Medical Branch At Galveston | Project Grant R01AI184551 | $224.0k | 9/13/24 |