This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) will support $639,084 in research to elucidate the heterogeneity and functional differences among naive CD8 T cells, which are the predecessors of antigen-experienced T cells. The 5-year project, awarded to Childrens Hospital Medical Center in Cincinnati, Ohio, aims to investigate both mouse and human naive CD8 T cell populations to understand how this heterogeneity is generated and maintained, with the goal of developing strategies to induce protective naive CD8 T cell immunity against pathogens and cancer. The research will involve examining antigen-specific CD8 T cells in young, aged, and newborn populations to define a comprehensive human naive CD8 T cell atlas. The findings from this project are expected to advance the understanding of naive T cell biology and inform the development of improved vaccines and immunotherapies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $639.1k | 3/19/25 |